腹腔镜单吻合口胃旁路术治疗肥胖与代谢综合征的近期疗效
Short-term efficacy of laparoscopic one anastomosis gastric bypass for obesity and metabolic syndrome
彭成娟 1黄洁 1周启阳 1穆丽茜1
作者信息
- 1. 苏州大学附属第一医院胃肠外科,苏州 215006
- 折叠
摘要
目的 分析腹腔镜单吻合口胃旁路术治疗肥胖与代谢综合征的近期疗效.方法 回顾性分析2020年10月至2022年9月期间行腹腔镜单吻合口胃旁路术治疗肥胖与代谢综合征患者的临床资料.结果 本组91例肥胖患者均成功实施腹腔镜单吻合口胃旁路手术,与术前相比,术后3个月患者的体重、BMI、多余体重减轻百分比均明显下降[(108.0±21.8)kg比(88.5±14.6)kg,F=100.740,P＜0.05;(38.9±6.3)kg/m2 比(31.9±3.9)kg/m2,F=194.708,P＜0.05;(52.6％±8.1％)],差异均有统计学意义.与术前相比,患者术后12个月空腹血糖、糖化血红蛋白、甘油三酯、低密度脂蛋白、尿酸均显著下降[(7.4±2.7)mmol/L 比(5.1±0.4)mmol/L,F=35.910,P＜0.05;(7.1％±1.8％)比(5.0％±0.4％),F=61.242,P＜0.05;(2.5±1.3)mmol/L 比(1.4±0.5)mmol/L,F=32.221,P＜0.05;(3.5±0.8)mmol/L 比(2.6±0.6)mmol/L,F=37.277,P＜0.05;(446.7±79.9)μmol/L 比(347.9±77.7)µmol/L,F=40.086,P＜0.05],高密度脂蛋白明显上升[(1.0±0.2)mmol/L 比(1.4±0.1)mmol/L,F=102.623,P＜0.05],差异均有统计学意义.在 45 例 2 型糖尿病患者中,1年后39例患者达到疾病缓解.术后共发生并发症7例,其中Clavien-DindoⅡ级及以上并发症4例,均通过相应处理后恢复.结论 腹腔镜单吻合口胃旁路术具有良好的减重效果,并能有效改善代谢症状.
Abstract
Objective To observe the short-term efficacy of laparoscopic one anastomosis gastric bypass(OAGB)in the treatment of obesity and metabolic syndrome.Method Clinical data of 91 patients with obesity and metabolic syndrome undergoing laparoscopic OAGB from Oct 2020 to Sep 2022 were analyzed.Result All 91 obese patients successfully underwent OAGB surgery,and their postoperative weight,BMI,and percentage of excess weight loss(％EWL)showed a significant decrease at 3 months after surgery[(108.0±21.8)kg vs.(88.5±14.6)kg,F=100.740,P＜0.05;(38.9±6.3)kg/m2vs.(31.9±3.9)kg/m2,F=194.708,P＜0.05;(52.6％±8.1％)].At 12 months after surgery,the fasting plasma glucose,glycated hemoglobin,triglycerides,low-density lipoprotein cholesterol,and uric acid significantly decreased[(7.4±2.7)mmol/L vs.(5.1±0.4)mmol/L,F=35.910,P＜0.05;(7.1％±1.8％)vs.(5.0％±0.4％),F=61.242,P＜0.05;(2.5±1.3)mmol/L vs.(1.4± 0.5)mmol/L,F=32.221,P＜0.05;(3.5±0.8)mmol/L vs.(2.6±0.6)mmol/L,F=37.277,P＜0.05;(446.7±79.9)μmol/L vs.(347.9±77.7)μmol/L,F=40.086,P＜0.05],while high-density lipoprotein cholesterol showed a significant increase[(1.0±0.2)mmol/L vs.(1.4±0.1)mmol/L,F=102.623,P＜0.05].In 45 patients with type 2 diabetes mellitus,39 patients achieved complete remission one year later.Seven patients suffered from postoperative complications,including 4 cases of Clavien-Dindo Ⅱ or above complications and recovered.Conclusion OAGB has a good weight loss effect and effectively improves metabolic symptoms.
关键词
肥胖症,病态/胃旁路术/代谢综合征/营养不良Key words
Obesity,morbid/Gastric bypass/Metabolic syndrome/Malnutrition引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据