PD-L1/B7-H3在肝内胆管癌中的表达及其与临床病理及预后的关系
Expression of PD-L1/B7-H3 in intrahepatic cholangiocarcinoma and its correlations with clinicopathological features and prognosis
张杰 1蒋斌 1张铃福 1原春辉 1凌晓锋 1修典荣1
作者信息
- 1. 北京大学第三医院普通外科,北京 100191
- 折叠
摘要
目的 探讨肝内胆管癌(intrahepatic cholangiocarcinoma,ICC)术后肿瘤组织PD-L1及B7-H3的表达情况及其与预后的关系.方法 回顾性分析2016年9月至2023年3月在北京大学第三医院接受手术治疗的63例ICC患者的临床和病理资料.结果 PD-L1、B7-H3分别在41.3％和60.3％的ICC患者中呈现高表达,且二者的表达状态存在相关性(P=0.005).PD-L1表达与肿瘤低分化相关(P=0.014),B7-H3高表达则与淋巴结转移相关(P=0.035).在PD-L1/B7-H3同时高表达的患者中,其总生存期(P=0.031)及无复发生存期(P=0.031)均显著缩短.PD-L1/B7-H3同时高表达是ICC术后复发(HR=3.998,95％CI:1.211～13.198;P=0.023)的独立危险因素.结论 在 ICC 患者中,PD-L1/B7-H3同时高表达者的预后较差,将二者作为联合生物标志物使用,在预测术后远期生存方面明显优于单独应用其中任一者.
Abstract
Objective To explore the expression of PD-L1 and B7-H3 in intrahepatic cholangiocarcinoma(ICC)and their relationship with the prognosis after surgery.Methods Clinicopathological data of 63 ICC patients undergoing surgery at the Department of General Surgery,Peking University Third Hospital,from Sep 2016 to Mar 2023 were retrospectively analyzed.Results PD-L1 and B7-H3 are highly expressed in 41.3％and 60.3％of ICC patients,respectively,and their expression levels were positively correlated with each other(P=0.005).High PD-L1 expression is significantly associated with poor tumor differentiation(P=0.014),while high B7-H3 expression is significantly related to lymph node metastasis(P=0.035).In patients with high co-expression of PD-L1 and B7-H3,the overall survival(P=0.031)and recurrence-free survival(P=0.031)were significantly decreased.High co-expression of PD-L1 and B7-H3 is an independent risk factor for recurrence in ICC(HR=3.998,95％CI:1.211-13.198;P=0.023).Conclusions ICC patients with high expression of both PD-L1 and B7-H3 have a poor prognosis.Using both as the combined biomarker significantly improves the prediction of long-term survival after surgery,compared to using either one alone.
关键词
胆管上皮癌/免疫组织化学/PD-L1/B7-H3/预后Key words
Cholangiocarcinoma/Immunohistochemistry/PD-L1/B7-H3/Prognosis引用本文复制引用
基金项目
科技创新新一代人工智能重大项目(2030)(2020AAA0105004)
北京大学第三医院临床队列建设项目(BYSYDL2023005)
出版年
2024
NETL
NSTL
万方数据