中华普通外科杂志2024,Vol.39Issue(7) :539-543.DOI:10.3760/cma.j.cn113855-20230327-00150

腹部皮瓣乳房再造术后并发症的危险因素分析

Risk factors of postoperative complications of breast reconstruction with abdominal flaps

苏聪 王庶 丁泊文 何珊珊 韩春勇 殷竹鸣 尹健
中华普通外科杂志2024,Vol.39Issue(7) :539-543.DOI:10.3760/cma.j.cn113855-20230327-00150

腹部皮瓣乳房再造术后并发症的危险因素分析

Risk factors of postoperative complications of breast reconstruction with abdominal flaps

苏聪 1王庶 1丁泊文 1何珊珊 1韩春勇 1殷竹鸣 1尹健1
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作者信息

  • 1. 天津医科大学肿瘤医院乳房再造科国家恶性肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津市恶性肿瘤临床医学研究中心乳腺癌防治教育部重点实验室中俄乳腺肿瘤整形联合研究中心,天津 300060
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摘要

目的 探讨腹部皮瓣乳房再造术后并发症及相关危险因素.方法 回顾性分析2011年1月至2022年4月天津医科大学肿瘤医院乳房再造科行腹部皮瓣乳房再造484例患者的临床资料.结果 484例患者中95例(19.6%)出现术后并发症,其中15.5%发生皮瓣并发症,5.2%发生供区并发症,脂肪坏死是发生率最高的并发症(11.9%),通过技术改进脂肪液化率较前大幅下降(1.7%比7.0%).单因素分析结果表明,再造术式、新辅助化疗史、BMI、吸烟史均与术后并发症有关(x2=21.088,P<0.001;x2=4.385,P=0.036;x2=14.784,P=0.018;x2=19.015,P=0.048),再造时机及术式均与非计划再次手术有关(x2=7.316,P=0.007;x2=17.167,P<0.001),再造时机、放疗时序均与修整手术有关(x2=40.785,P<0.001;x2=18.602,P<0.001);多因素分析结果表明,腹壁下动脉穿支皮瓣、吸烟史是皮瓣坏死的独立危险因素(OR=0.084,95%CI:0.022~0.325,P<0.001;OR=41.623,95%CI:3.241~534.569,P=0.004).结论 腹部皮瓣乳房再造术后并发症与多种因素有关,术前应详细评估手术风险,制定个性化方案.

Abstract

Objective To study the postoperative complications and its risk factors in patients undergoing breast reconstruction with abdominal flaps.Methods The clinical data of patients undergoing breast reconstruction with abdominal flaps at Department of Breast Oncoplastic Surgery,Tianjin Medical University Cancer Institute and Hospital from Jan 2011 to Apr 2022 were reviewed.Results Postoperative complications occurred in 95 of 484 patients(19.6%),15.5%had flap complications,5.2%had donor-site complications,and fat necrosis was the most common complication(11.9%).The rate of fat liquefaction decreased significantly through technical improvement(1.7%vs.7.0%);By univariate analysis,there were statistically significant differences among the groups by reconstructive type,neoadjuvant chemotherapy,BMI,smoking history(x2=21.088,P<0.001;x2=4.385,P=0.036;x2=14.784,P=0.018;x2=19.015,P=0.048).Unplanned reoperation statistically related to the timing of reconstruction,and reconstructive type(x2=7.316,P=0.007;x2=17.167,P<0.001).Revision surgery significantly related to the timing of reconstruction and timing of radiation(x2=40.785,P<0.001;x2=18.602,P<0.001);By multivariate analysis,deep inferior epigastric perforator flap,smoking history were independent risk factors for flap necrosis(OR=0.084,95%CI:0.022-0.325,P<0.001;OR=41.623,95%CI:3.241-534.569,P=0.004).Conclusions Complications after breast reconstruction with abdominal flaps are related to many factors.The surgical risks should be carefully evaluated and personalized plan should be formulated before surgery.

关键词

乳房成形术/术后并发症/危险因素

Key words

Mammaplasty/Postoperative complications/Risk factors

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基金项目

天津市医学重点学科(专科)建设项目基金资助项目(TJYXZDXK-009A)

天津市"项目+团队"重点培养专项基金资助项目(XB202008)

出版年

2024
中华普通外科杂志
中华医学会

中华普通外科杂志

CSTPCD北大核心
影响因子:1.11
ISSN:1007-631X
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