Objective To investigate the predictive value of Naples prognostic score(NPS)in assessing the overall survival of intrahepatic cholangiocarcinoma(ICC)patients after receiving hepatectomy treatment.Methods Clinicopathological characteristics and follow-up data of 164 ICC patients who underwent curative hepatectomy at Zhejiang Cancer Hospital from Jan 2010 to Aug 2022 were retrospectively collected.NPS was calculated basing on preoperative serum albumin concentration,total cholesterol concentration,the neutrophil-lymphocyte ratio,and lymphocyte-monocyte ratio.The relationship between NPS and overall survival was analyzed,and the efficacy of NPS in predicting long-term survival was compared to TNM staging system and other independent risk factors.Results Multivariate analysis identified the NPS[Score 1 versus 0:1.864(1.011-3.437),P=0.046;Score 2 versus 0:3.013(1.465-6.199),P=0.003]as an independent risk factor for overall survival.The area under curve(AUC)of the rece 中 iver operating characteristic(ROC)curve for predicting 5-year OS based on NPS is 0.75,which is higher than TNM staging(0.59)and other independent risk factors(CA19-9:0.71,lymph node metastasis:0.66,tumor size:0.62,microvascular invasion:0.56).Conclusion NPS as an independent predictor of overall survival for ICC patients,is more accurate than TNM staging system and other clinicopathological factors.
关键词
胆管上皮癌/存活率/Naples预后评分/曲线下面积
Key words
Cholangiocarcinoma/Survival rate/Naples prognostic score/Area under the curve
维普
万方数据