摘要
目的 探讨胃癌患者神经内分泌功能对术后并发症及营养状况的影响.方法 回顾性分析2021年8月至2022年6月在苏州大学第一附属医院普外科接受胃癌根治术的102例胃癌患者的临床资料.结果 102例胃癌患者中,18例(17.6％)发生了术后并发症.单因素分析结果显示年龄、BMI、术前血浆胃促生长素浓度、术前血红蛋白量与胃癌根治术后早期并发症有关.多因素分析结果显示年龄、BMI、术前血浆胃促生长素浓度是胃癌患者术后并发症发生的独立危险因素(P＜0.05).胃促生长素浓度的差异性分析显示胃促生长素浓度和患者血红蛋白量、骨骼肌指数(SMI)、白蛋白和肌酐相关,且和SMI呈正相关.结论 胃癌患者术前神经内分泌激素胃促生长素浓度降低是术后并发症的独立危险因素,胃促生长素浓度与胃癌患者的SMI相关.
Abstract
Objective To investigate the impact of neuroendocrine function on postoperative complications and nutritional status in gastric cancer patients.Methods Clinical data of 102 gastric cancer patients who underwent radical gastrectomy at the Department of General Surgery,First Affiliated Hospital of Soochow University,from Aug 2021 to Jun 2022 were retrospectively analyzed.Results Among the 102 gastric cancer patients,18(17.6％)suffered from postoperative complications.Univariate analysis indicated that age,BMI,preoperative plasma ghrelin concentration,and preoperative hemoglobin levels were associated with early postoperative complications following radical gastrectomy.Multivariate analysis revealed that age,BMI,and preoperative plasma ghrelin concentration(P＜0.05)were independent risk factors for postoperative complications in gastric cancer patients.Differential analysis of ghrelin concentration demonstrated correlations with hemoglobin levels,skeletal muscle index,albumin,and creatinine,and a positive correlation with the skeletal muscle index.Conclusions Reduced preoperative neuroendocrine hormone ghrelin concentration is an independent risk factor for postoperative complications in gastric cancer patients.Ghrelin concentration is correlated with the skeletal muscle index in these patients.
基金项目
国家自然科学基金(81871952)
国家自然科学基金(82372887)
江苏省自然科学基金(BK20221242)
苏州市第五批姑苏卫生人才培养项目(GSWS2019008)
江苏高校"青蓝工程"项目()
苏州市临床重点病种诊疗技术专项项目(LCZX202202)
苏州大学苏州医学院"临床医学高峰项目"()
苏州大学附属第一医院"博习优才铸造计划"领军人才项目()
苏州市"科教兴卫"青年科技项目(KJXW2023005)
苏州大学附属第一医院博习培育计划项目(BXQN2023027)
维普
万方数据