16例原发性甲状腺鳞状细胞癌的临床病理特征及预后分析
Clinicopathologic features and prognosis of primary squamous cell carcinoma of the thyroid:report of 16 patients
张玮 1胡传祥 1胡琳斐 1程文元 1郑向前1
作者信息
- 1. 天津医科大学肿瘤医院甲状腺颈部肿瘤科 国家恶性肿瘤临床医学研究中心 天津市恶性肿瘤临床医学研究中心 天津市肿瘤防治重点实验室,天津 300060
- 折叠
摘要
目的 分析原发性甲状腺鳞状细胞癌的临床病理特征及预后因素.方法 回顾性分析2012年1月至2016年12月在天津医科大学肿瘤医院收治的16例原发性甲状腺鳞状细胞癌患者的临床资料,并分析其临床病理特征及影响预后的因素.结果 本组16例原发性甲状腺鳞状细胞癌中男6例(38％),女10例(62％),平均年龄为(58.13±11.21)岁.单因素分析和Log-rank检验模型结果显示,影响患者生存的因素是性别(x2=4.367,P=0.037)、肿瘤大小(x2=5.630,P=0.018)及是否行根治性手术(x2=11.123,P=0.001).COX回归分析显示影响患者生存的独立危险因素为是否行根治性手术(P=0.034).结论 原发性甲状腺鳞状细胞癌是一种罕见的甲状腺恶性肿瘤,侵袭性强,预后差,行根治性手术治疗可以明显改善患者的预后.
Abstract
Objective To evaluate the clinicopathologic characteristics and prognosis of primary squamous cell carcinoma of the thyroid(PSCCT).Methods We reported 16 cases who were operated on and histologically diagnosed with primary squamous cell carcinoma of the thyroid from Jan 2012 to Dec 2016.Results Among the 16 patients with PSCCT,there were 10 females(62％)and 6 males(38％),mean age was(58.13±11.21)years old.Univariate analysis showed that gender(x2=4.367,P=0.037),tumor size(x2=5.630,P=0.018)and radical surgery(x2=11.123,P=0.001)were important predictive factors for overall survival.COX regressing analysis showed radical surgery was independent prognostic factors(P=0.034).Conclusions PSCCT is a rare thyroid cancer with an aggressive nature and poor prognosis.Radical surgery was associated with a fair outcome.
关键词
甲状腺肿瘤/病理学,临床/预后Key words
Thyroid neoplasms/Pathology,clinical/Prognosis引用本文复制引用
出版年
2024
NETL
NSTL
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