肿瘤负荷评分联合术前控制营养状态评分对肝细胞癌患者根治性切除术后预后的预测价值
Predict value of tumor burden score combined with preoperative controlling nutritional status score on prognosis of patients with hepatocellular carcinoma after radical hepatectomy
魏星博 1职意凡 1王连才 1李冬筱 2肖二卫 1李德宇1
作者信息
- 1. 河南大学人民医院肝胆胰腺外科,郑州 450003
- 2. 郑州大学人民医院消化内科,郑州 450003
- 折叠
摘要
目的 探讨肿瘤负荷评分(tumor burden score,TBS)联合术前控制营养状态(controlling nutritional status,COUNT)评分对肝细胞癌(hepatocellular carcinoma,HCC)患者根治性切除术后预后的影响.方法 回顾性分析2017年1月至2020年12月在河南大学人民医院行根治性切除术的165例HCC患者的临床及随访资料.受试者工作特征(receiver operating characteristic,ROC)曲线评价TBS-COUNT评分对HCC患者术后预后的预测效能.结果 中位随访时间17.0个月.TBS-COUNT评分预测HCC患者术后3年生存率和复发率的曲线下面积(area under curve,AUC)分别为0.802和0.771(均P＜0.05).低风险组与高风险组患者术后1、3年累积生存率分别为98.65％、71.62％和82.42％、47.76％(均P＜0.05);低风险组与高风险组患者术后1、3年无复发生存率分别为87.84％、25.68％和42.86％、4.40％(均P＜0.05).多因素COX回归分析显示TBS-COUNT评分是影响HCC患者术后总生存率(HR=2.14,95％CI:1.04～4.42,P=0.040)和无复发生存率(HR=2.16,95％C/:1.07～4.35,P=0.032)的独立危险因素.结论 TBS-COUNT评分是预测肝细胞癌患者根治性切除术后预后的有效指标.
Abstract
Objective To investigate the effect of tumor burden score(TBS)combined with preoperative control nutritional status(COUNT)score on prognosis of hepatocellular carcinoma patients after radical hepatectomy.Methods The clinical and follow-up data of 165 HCC patients who underwent radical hepatectomy at People's Hospital,Henan University from Jan 2017 to Dec 2020 were retrospectively analyzed.Receiver operating characteristic(ROC)was used to evaluate the prognostic efficacy of TBS-COUNT score.Results The median follow-up time was 17.0 months.The area under curve(AUC)of TBS-COUNT score for predicting 3-year postoperative survival and recurrence rate of HCC patients was 0.802 and 0.771,respectively(P＜0.05).The 1-,and 3-year cumulative survival rates in low-risk and high-risk groups were 98.65％,71.62％and 82.42％,47.76％respectively(all P＜0.05).The 1-,and 3-year recurrence free survival rates were 87.84％,25.68％and 42.86％,4.40％in the low-risk group and the high-risk group,respectively(all P＜0.05).Multivariate COX regression analysis showed that TBS-COUNT score is an independent risk factor for post-operative OS(HR=2.14,95％CI:1.04-4.42,P=0.040)and RFS(HR=2.16,95％CI:1.07-4.35,P=0.032)in HCC patients.Conclusion TBS-COUNT score is an effective predictor of prognosis of hepatocellular carcinoma patients after radical resection.
关键词
癌,肝细胞/肝切除术/肿瘤负荷评分/控制营养状态评分/预后Key words
Carcinoma,hepatocellular/Hepatectomy/Tumor burden score/Controlling nutritional status score/Prognosis引用本文复制引用
出版年
2024
NETL
NSTL
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