Objective To investigate the effect of high glucose on invasion and migration of colorectal cancer(CRC)through hepatocyte growth factor(HGF)/c-met pathway.Methods Forty CRC patients from January 2022 to December 2022 were selected and divided into hyperglycemic group(blood glucose ≥6.1 mmol/L,n=22)and normal blood glucose group(blood glucose 3.96.1 mmol/L,n=18)according to fasting blood glucose.The clinicopathological features and high expression rates of HGF and c-met were compared between the two groups.HCT116 cells were divided into control group(n=5),high glucose group(n=5)and high glucose+sull274 group(n=5).The proliferation,invasion,migration,HGF and c-met protein expression levels of the three groups were compared.SPSS 20.0 statistical software was used to process the data.The measurement data were expressed as((x)±s).One-way ANOVA analysis of variance was used for multi-group comparison,and LSD-t test was used for pin-group comparison.The comparison of counting data between the two groups was performed using the x2 test.P＜0.05 was considered statistically significant.Results The proportion of CRC differentiation and lymph node metastasis in hyperglycemia group were higher than those in normal glycemia group(P＜0.05).The high expression rates of HGF and c-met in hyperglycemia group were higher than those in normal blood glucose group(P＜0.05).Compared with the control group,the proliferation activity,invasion,migration,HGF and c-met protein expression levels of HCT116 cells in high glucose group were increased,with statistical significance(P＜0.05).Compared with the high sugar group,the above indexes in the high sugar+sull274 group were lower,and the difference was statistically significant(P＜0.05).Conclusion High glucose can promote CRC invasion and migration by upregulating HGF/c-met pathway.
维普
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