Gastrointestinal tumor is a major tumor disease affecting people all over the world.The existing therapeutic strategies have expanded from simply targeting the tumor itself to targeting the tumor microenvironment in the past.Among them,immunotherapy represented by immune control point molecular inhibitors is the latest and most popular research field,and the corresponding therapeutic means have gradually been widely used in the treatment of gastrointestinal tumor.However,the percentage of people who benefit from immunotherapy is still relatively low,which is closely related to the complex microenvironment of gastrointestinal tumors.As an important component of regulating immune response,the nervous system plays an important role in tumor immunity.An in-depth study of the role of the nervous system in gastrointestinal tumor immune response will not only provide help for a comprehensive understanding of tumor immune regulation and the development of immunotherapy strategies,but also provide an important theoretical basis for the development of functional surgery such as vagus nerve preservation.In this review,the relevant fields will be systematically summarized to lay a theoretical foundation for revealing the immune response of gastrointestinal tumors.
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