The purpose of this study was to investigate the role of microRNA(miRNA)in triple negative breast cancer(TNBC).This paper focuses on the background and clinical features of TNBC,as well as the basic concepts and regulatory mechanisms of mirnas.The molecular characteristics of TNBC were described in detail,including differences in gene expression profiles and abnormal activation of signaling pathways,as well as the role of microRNA in TNBC.The role of microRNA in the progression of TNBC was further discussed,including its expression profile,potential as a prognostic marker for TNBC,and prospect as a therapeutic target for TNBC.The detection and analysis methods of microRNA and the research strategies based on high-throughput sequencing were reviewed.This review summarizes the understanding of the role of micrornas in the progression of TNBC,and identifies priorities and challenges for future research,including the discovery and validation of new miRNA targets,the identification of mechanisms of miRNA regulatory networks,and the development of therapeutic strategies targeting micrornas.
维普
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