摘要
目的:探究3D腹腔镜袖状胃切除术（LSG）在治疗2型糖尿病（T2DM）合并肥胖症患者中的临床疗效，分析LSG在治疗T2DM中的影响因素。方法:回顾性分析2019年1月至2022年1月接受LSG治疗的65例T2DM肥胖患者的临床资料，分别在术后第1月、3月、6月和12月进行随访。使用SPSS 26.0统计软件进行数据分析，手术前后BMI、血糖、血脂等计量资料以（）表示，采用独立样本t检验。计数资料采用χ2检验分析。采用Logistics 回归分析临床疗效的影响因素。P<0.05为差异有统计学意义。结果:所有患者均完成了术后随访，随访率100%。BMI、空腹血糖（FPG）、C肽、糖化血红蛋白（HbA1c）、总胆固醇（CHOL）、甘油三酯（TG）和空腹胰岛素水平（FINS）在术后1年都得到了缓解。多变量分析显示，T2DM病程、C肽和FINS是影响LSG后T2DM疗效的因素。结论:LSG在减轻体重的同时对T2DM患者有明显的治疗效果，但其长期疗效尚需要进一步验证。
Abstract
Objective:To study 3D laparoscopic sleeve gastrectomy (LSG) in the treatment of type 2 diabetes mellitus (T2DM) combined with obesity and observe its clinical efficacy, and analyze the factors influencing LSG in the treatment of T2DM.Methods:Clinical data of 65 obese patients with T2DM treated with LSG from January 2019 to January 2022 were reviewed and analyzed. Follow-up was performed at months 1, 3, 6, and 12 within 1 year after surgery. Statistical analysis was performed using SPSS 26.0, and the measurement data were expressed as () deviation with independent samples t test. Count data were analyzed using the χ2 test, and logistic regression analysis was used to investigate the multiple factors affecting clinical outcomes. Differences were considered statistically significant at P<0.05.Results:All patients completed 1-year postoperative follow-up, and no patients dropped out. BMI, fasting glucose (FPG), fasting C-peptide, hemoglobin A1c (HbA1c), total cholesterol (CHOL), triglycerides (TG), and fasting insulin levels (FINS) were all in remission at 1 year postoperatively. Multivariate analysis showed that the duration of T2DM disease, C-peptide, and FINS were factors influencing the efficacy of T2DM after LSG.Conclusion:LSG has a significant therapeutic effect on T2DM patients while reducing body weight, but its long-term efficacy needs further validation.
基金项目
国家自然科学基金资助项目(81972269)
消化病代谢病基础与临床转化重点实验室项目(YZ2020159)
万方数据