摘要
目的:探讨维生素D水平与亚急性甲状腺炎（SAT）预后的相关性。方法:回顾性分析2020年3月至2022年3月170例SAT患者（SAT组）和86例健康体检者（对照组）的临床资料，对比25-羟基维生素D [25(OH)D]水平并进行分析。数据分析用SPSS 26.0软件。甲状腺功能检测值、血清检测值等计量资料以（）表示，行独立样本t检验；计数资料以[例（%）]表示，采用χ2检验分析。P<0.05为差异有统计学意义。结果:SAT组患者的红细胞沉降率（ESR）、C反应蛋白（CRP）、白细胞计数（WBC）、游离三碘甲腺原氨酸（FT3）及游离甲状腺素T4（FT4）值均高于对照组（P<0.001），25(OH)D、TSH值低于正常对照组（P<0.001）；26例复发患者的25(OH)D水平为（12.8±1.6）ng/ml，低于非复发患者的（14.2±1.9）ng/ml，差异有统计学意义（P=0.017）。170名SAT患者治疗后永久性甲状腺功能减退17例（10.0%），但与非甲减患者25(OH)D水平差异无统计学意义（P=0.71）。结论:亚急性甲状腺炎治疗后复发患者的维生素D水平明显低于非复发患者，说明可针对性补充降低其复发率。
Abstract
Objective:To investigate the correlation between vitamin D level and prognosis of subacute thyroiditis (SAT).Methods:The clinical data of 170 SAT patients (SAT group) and 86 healthy subjects (control group) from March 2020 to March 2022 were retrospectively analyzed, and the 25-hydroxyvitamin D [25(OH)D] levels were compared and analyzed. SPSS 26.0 software was used for data analysis. Measurement data such as thyroid function test value and serum test value were expressed as (), and independent sample t test was performed. The statistical data were represented by [example (%)] and χ2 analysis was used. P<0.05 was considered statistically significant.Results:The values of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), white blood cell count (WBC), free triiodothyronine (FT3) and free thyroxine T4 (FT4) in SAT group were higher than those in control group (P<0.001), and the values of 25(OH)D and TSH were lower than those in normal control group (P<0.001). The 25(OH)D level of 26 patients with relapse was (12.8±1.6) ng/ml, which was lower than that of non-relapse patients (14.2±1.9) ng/ml, and the difference was statistically significant (P=0.017). Among 170 SAT patients, 17 (10.0%) had permanent hypothyroidism after treatment, but there was no significant difference in 25(OH)D level between SAT and non-hypothyroidism patients (P=0.71).Conclusion:The level of vitamin D in patients with recurrent subacute thyroiditis after treatment is significantly lower than that in non-recurrent patients, indicating that targeted supplementation can reduce the recurrence rate.
基金项目
河北省卫生健康委员会科研基金项目(20231417)
万方数据