首页|肾移植供者特异性抗体和抗体介导排斥反应的国际前沿热点、进展及其临床思考

肾移植供者特异性抗体和抗体介导排斥反应的国际前沿热点、进展及其临床思考

International frontier hot spots and recent advances of donor specific antibody and antibody-mediated rejection after kidney transplantation

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本文对肾移植供者特异性抗体(donor specific antibody,DSA)以及抗体介导的排斥反应(antibody-mediated rejection,AMR)国际前沿热点及新进展做概要论述,包括:DSA的新认识、风险分层、非HLA抗体对移植肾的损害、去致敏及AMR治疗新方法和应用策略,以及如何平衡AMR防治与感染风险,并结合自身移植临床实践提出思考与评价.
This review summarized the international hot topics and recent advances of donor specific antibody(DSA)and antibody-mediated rejection(AMR)after kidney transplantation,including a novel understanding of DSA,risk stratification,non-HLA antibody impairments,new application strategies of desensitization and AMR treatment,as well as striking a balance between AMR management and infection risk.Also institutional reflections and evaluations were discussed based upon clinical practices.

Kidney transplantationDonor specific antibodyAntibody-mediated rejectionRecent advance

王祥慧、安会敏

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上海交通大学医学院附属瑞金医院泌尿外科肾脏移植中心,上海 200025

肾移植 供者特异性抗体 抗体介导的排斥反应 进展

国家自然科学基金

81973387

2024

中华器官移植杂志
中华医学会

中华器官移植杂志

CSTPCD
影响因子:0.574
ISSN:0254-1785
年,卷(期):2024.45(1)
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