International frontier hot spots and recent advances of donor specific antibody and antibody-mediated rejection after kidney transplantation
王祥慧 1安会敏1
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作者信息
1. 上海交通大学医学院附属瑞金医院泌尿外科肾脏移植中心,上海 200025
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摘要
本文对肾移植供者特异性抗体(donor specific antibody,DSA)以及抗体介导的排斥反应(antibody-mediated rejection,AMR)国际前沿热点及新进展做概要论述,包括:DSA的新认识、风险分层、非HLA抗体对移植肾的损害、去致敏及AMR治疗新方法和应用策略,以及如何平衡AMR防治与感染风险,并结合自身移植临床实践提出思考与评价.
Abstract
This review summarized the international hot topics and recent advances of donor specific antibody(DSA)and antibody-mediated rejection(AMR)after kidney transplantation,including a novel understanding of DSA,risk stratification,non-HLA antibody impairments,new application strategies of desensitization and AMR treatment,as well as striking a balance between AMR management and infection risk.Also institutional reflections and evaluations were discussed based upon clinical practices.
关键词
肾移植/供者特异性抗体/抗体介导的排斥反应/进展
Key words
Kidney transplantation/Donor specific antibody/Antibody-mediated rejection/Recent advance
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