International frontier hot spots and recent advances of donor specific antibody and antibody-mediated rejection after kidney transplantation
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维普
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本文对肾移植供者特异性抗体(donor specific antibody,DSA)以及抗体介导的排斥反应(antibody-mediated rejection,AMR)国际前沿热点及新进展做概要论述,包括:DSA的新认识、风险分层、非HLA抗体对移植肾的损害、去致敏及AMR治疗新方法和应用策略,以及如何平衡AMR防治与感染风险,并结合自身移植临床实践提出思考与评价.
This review summarized the international hot topics and recent advances of donor specific antibody(DSA)and antibody-mediated rejection(AMR)after kidney transplantation,including a novel understanding of DSA,risk stratification,non-HLA antibody impairments,new application strategies of desensitization and AMR treatment,as well as striking a balance between AMR management and infection risk.Also institutional reflections and evaluations were discussed based upon clinical practices.
Kidney transplantationDonor specific antibodyAntibody-mediated rejectionRecent advance