Predictive value of contrast-enhanced ultrasound plus transient elastography for early allograft dys-function after liver transplantation from C-I donors
Objective Exploring the value of contrast enhanced ultrasound(CEUS)plus transient elastography in evaluating donor livers for C-I donors and predicting the occurrence of early allograft dysfunction(EAD).Methods Between September 1,2022 and August 31,2023,the relevant clinical data were retrospectively reviewed for 75 pairs of donors and recipients.Based upon whether or not there was a postoperative onset of EAD,the recipients were assigned into two groups of EAD(16 cases)and non-EAD(59 cases).All donors were examined by contrast-enhanced ultrasonography and FibroScan.QLAB analysis software was utilized for analyzing the results of contrast-enhanced ultrasound.Liver parenchyma at 3 cm below liver capsule was selected as a region of interest for plotting the time-intensity curve(TIC).And the contrast-enhanced ultrasonic parameters of two groups were recorded.FibroScan transient elastography instrument was employed for quantifying liver stiffness 12 times in right lobe of donor liver and recording quantitative parameters of liver stiffness measurement(LSM)and controlled attenuation parameter(CAP).Results Inter-group comparison of gender,age,body mass index(BMI)and ICU length of stay showed no statistically significant differences(P＞0.05).However,significant differences existed in the levels of platelet[(122.44±85.82)vs(197.22± 140.93)× 109/L]and cholinesterase[(3 473.44±1 368.54)vs(4 252.93±1 365.37)U/L]within the first 24h pre-operation(P=0.047,P=0.047).Peak intensity(PKI)and area under the curve(AUC)were lower in EAD group than those in non-EAD group[(16.44±4.70)dB vs 19.85±4.39 dB,P=0.009;(1 366.76±508.10)dB·s vs(1 675.23±498.77)dB·s,P=0.014].There were statistically significant differences(P=0.009,P=0.032).Arterial-portal arrival interval(APAI)and LSM were higher in EAD group than those in non-EAD group[6.50(5.00,10.75)s vs 5.00(4.00,7.00)s,P=0.24;8.60(6.32,11.65)kPa vs 6.10(5.40,7.90)kPa,P=0.014].Receiver operating characteristic(ROC)curve analysis revealed that PKI,AUC,APAI and LSM had AUC values of 0.703,0.664,0.683 and 0.702,respectively in predicting postoperative EAD.And combined prediction of EAD occurrence based upon these parameters had an AUC of 0.776,a Youden index of 0.508 with cutoff values,sensitivity and specificity of 0.800,0.813 and 0.695 respectively.Spearman's correlation analysis revealed a negative correlation between APAI and AUC values(r=-0.404,P＜0.001).Conclusions The combination of CEUS and transient elastography can comprehensively evaluate the status of microcirculatory perfusion,fibrosis and steatosis of liver grafts from brain death donors.It offers a great predictive value for postoperative occurrence of EAD.
NETL
NSTL
万方数据
