Objective To explore the long-term therapeutic efficacy and outcomes of liver transplantation for patients with hepatic myelopathy(HM).Methods Retrospective analysis of 24 adult liver transplantation recipients due to HM at First Central Municipal Hospital from January 2006 to October 2022.HM was extensively classified by the severity of lower extremity symptoms,degree of muscle stiffness,capability for independent ambulation and muscle strength.Furthermore,their long-term outcomes were examined.From January 2000 to October 2022,the databases of China National Knowledge Infrastructure(CNKI),Google Scholar,PubMed and Web of Science were searched with such keywords as"肝性脊髓病and肝移植""Hepatic Myelopathy and Liver Transplantation".Results After liver transplantation,liver functions and blood ammonia normalized and most clinical symptoms improved.During a follow-up period of(12-190)months,19 patients showed a lowered grade of HC as compared to pre-transplantation.Four cases achieved a complete recovery of extremity function.No change occurred in severity grade for the remaining 5 patients.However,4 of them experienced varying degrees of improvement in muscle strength and independent walking capability.This review summarized the clinical characteristics and clinical outcomes of 17 patients from both domestic and international sources.Most of them experiences varying degrees of symptomatic improvements after liver transplantation(16 cases).Conclusions This study has confirmed the effectiveness of liver transplantation for HM and its contribution to the long-term patient recovery.
关键词
肝移植/肝性脊髓病/脊髓疾病/远期疗效
Key words
Liver transplantation/Hepatic myelopathy/Diseases of spinal cord/Long-term effect
维普
万方数据