Applications and advances of desensitizing therapeutic agents in pre-sensitized renal transplantation
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肾移植是治疗终末期肾脏病的主要方式之一，不同中心报道的移植肾10年存活率在75%~80%。研究认为，肾移植是目前降低肾功能衰竭全因死亡率的最佳治疗方式，可明显改善受者生存率与生活质量。预致敏受者由于体内预存有抗人类白细胞抗原抗体，其移植术后发生排斥的风险远高于非致敏受者，但目前随着各类脱敏技术的应用，此类受者的移植率以及术后受者/移植肾存活率已逐渐升高，致敏不再是肾移植的禁忌证。本文主要就预致敏肾移植脱敏治疗药物的进展进行综述和展望。 Kidney transplantation (KT) is one primary treatment of end-stage renal disease (ESRD). As reported by different centers, 10-year survival rate of transplanted kidneys fluctuates from 75% to 80%. Capable of reducing all-cause mortality in renal failure, KT can significantly improve survival rate and quality-of-life of ESRD patients. The risk of post-transplant rejection is much higher in pre-sensitised recipients than in non-sensitised ones due to the pre-existing anti-human leukocyte antigen antibodies. However, with a rapid development of various desensitisation techniques, transplantation rate and postoperative human/kidney survival rate of recipients have been greatly enhanced. And presensitisation is no longer a contraindication to KT. This review focused upon the latest advances in desensitisation therapeutic agents for pre-sensitised KT.
Kidney transplantation (KT) is one primary treatment of end-stage renal disease (ESRD). As reported by different centers, 10-year survival rate of transplanted kidneys fluctuates from 75% to 80%. Capable of reducing all-cause mortality in renal failure, KT can significantly improve survival rate and quality-of-life of ESRD patients. The risk of post-transplant rejection is much higher in pre-sensitised recipients than in non-sensitised ones due to the pre-existing anti-human leukocyte antigen antibodies. However, with a rapid development of various desensitisation techniques, transplantation rate and postoperative human/kidney survival rate of recipients have been greatly enhanced. And presensitisation is no longer a contraindication to KT. This review focused upon the latest advances in desensitisation therapeutic agents for pre-sensitised KT.
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