To address the global shortage of donor organs,marginal donated livers are increasingly used in liver transplants,albeit with associated risks such as early graft dysfunction and primary non-function.Improving the quality of marginal donated livers is one of the focal areas in transplantation research.Machine perfusion is pivotal in this effort,reducing ischemia-reperfusion injuries and enhancing liver quality.Recently,advances in cell and gene therapy,combined with optimized machine perfusion strategies,have enabled precise interventions for specific organs,showing great potential in improving marginal donated liver quality and increasing recipient survival rates.These innovations have the potential to drive advancements in machine perfusion and organ repair and regeneration technologies.
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