中华器官移植杂志2024,Vol.45Issue(12) :900-902.DOI:10.3760/cma.j.cn421203-20230917-00096

肝豆状核变性行肝移植术后早期分娩1例

Delivery in early post-liver transplantation period in a patient with Wilson's disease:one case report

李国耀 谢炎 孙岩岩 吕兵 孙纪三
中华器官移植杂志2024,Vol.45Issue(12) :900-902.DOI:10.3760/cma.j.cn421203-20230917-00096

肝豆状核变性行肝移植术后早期分娩1例

Delivery in early post-liver transplantation period in a patient with Wilson's disease:one case report

李国耀 1谢炎 1孙岩岩 1吕兵 1孙纪三1
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作者信息

  • 1. 天津市第一中心医院器官移植中心,天津市器官移植临床医学研究中心,天津市器官移植重点实验室,天津 300192
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摘要

通过回顾1例移植术前有习惯性流产的肝豆状核变性患者,因肝功能失代偿接受原位肝移植手术并于术后9个月妊娠且成功分娩的临床资料,探讨肝移植对肝豆状核变性患者妊娠的影响,并对相关文献进行复习.该例受者术后已随访4年余,产妇及幼儿均体健.这一结果提示,肝移植手术可能可以提高肝豆状核变性受者的妊娠成功率.妊娠期间应继续进行抗排斥治疗,同时要注意避免使用哺乳动物雷帕霉素靶蛋白抑制剂、霉酚酸酯和硫唑嘌呤类药物.

Abstract

The relevant clinical data were reviewed for a female patient of Wilson's disease(WD)with habitual abortion.After orthotopic liver transplantation(LT)due to liver dysfunction compensation,she became pregnant and successfully delivered a healthy baby at Month 9 post-LT.This study explored the impact of LT on pregnancy in WD patients and reviewed the related literature.The recipient has been followed up for over 4 years post-LT.Both mother and child are healthy.It suggested that LT surgery can boost the pregnancy success rate of WD patients.Immunosuppressants may be maintained during pregnancy while avoiding the dosing of mTOR inhibitors,mycophenolate mofetil and azathioprine.

关键词

肝移植/肝豆状核变性/妊娠/流产

Key words

Liver transplantation/Wilson's disease/Pregnancy/Abortion

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出版年

2024
中华器官移植杂志
中华医学会

中华器官移植杂志

CSTPCD
影响因子:0.574
ISSN:0254-1785
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