Acute graft-versus-host disease after simultaneous pancreas and kidney transplantation:one case report
胡露 1郑建明 2粘烨琦 2王振 2王辉 2冯钢 2赵杰 2宋文利2
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作者信息
1. 天津医科大学一中心临床学院,天津 300041
2. 天津市第一中心医院胰腺移植科,天津 300192
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摘要
本研究报告1例胰肾联合移植术后急性移植物抗宿主病(acute graft versus host disease,aGVHD).受者于术后第17天陆续出现包括发热、肝功能指标异常、肠梗阻、皮疹和骨髓抑制等典型临床表现,血液中供者来源细胞游离DNA(donor-derived cell-free DNA,dd-cf DNA)占比为8.66％,诊断为aGVHD,给予大剂量糖皮质激素冲击等治疗.受者病情进展迅速,术后第24天死于多器官功能衰竭.
Abstract
One case of acute graft-versus-host disease(aGVHD)after simultaneous pancreas and kidney(SPK)transplantation was described.The recipient exhibited typical clinical manifestations,including fever,abnormal liver function tests,intestinal obstruction,rash and myelosuppression since Day 17 post-SPK.The proportion of donor-derived cell-free DNA(dd-cfDNA)in blood was 8.66％,confirming a diagnosis of aGVHD.Despite high-dose glucocorticoid pulse therapy,patient status rapidly deteriorated and death due to multi-organ failure occurred at Day 24 post-SPK.
关键词
胰肾联合移植/急性移植物抗宿主病/并发症
Key words
Simultaneous pancreas-kidney transplantation/Acute graft versus host disease/Complication
万方数据