摘要
目的:分析高分辨率食管测压（HREM）在胃食管反流病（GERD）食管运动功能评估中的应用效果。方法:选取2018年1月至2022年12月，中国人民解放军火箭军特色医学中心300例GERD患者（观察组）与同期300例无反流症状，且胃镜检查未见异常的正常者（对照组），2组均采用HREM监测，分析检测结果。结果:2组患者食团内部压力、食管长度、远端收缩延迟时间、下食管括约肌长度（LESL）比较，差异均无统计学意义（P>0.05）；观察组收缩前沿速度（CFV）明显高于对照组，食管下括约肌静息压（LESP）、远端收缩积分（DCI）明显低于对照组，差异均有统计学意义（P<0.05）。观察组反流持续≥5 min次数、pH<4总时间、最长反流持续时间、pH<4的反流次数、立位和卧位pH<4的时间百分比均较对照组高，差异均有统计学意义（P<0.05）。结论:HREM在GERD食管运动功能评价中应用价值较高，能够准确地反映GERD相关食管运动情况。
Abstract
Objective:To analyze the application effect of high resolution esophageal manometry (HREM) in the evaluation of esophageal motor function in gastroesophageal reflux disease (GERD).Methods:300 patients with GERD (observation group) and 300 normal patients with no reflux symptoms and no abnormal gastroscopy (control group) were selected from the Special Medical Center of the Chinese People's Liberation Army Rocket Force from January 2018 to December 2022. HREM was performed in both groups and the detection results were analyzed.Results:In terms of internal bolus pressure (IBP), esophageal length, distallatency delay time (DL), and low esophageal sphincter length (LESL), there was no significant difference between the two groups (P>0.05). The contractile front velocity (CFV) in the observation group was significantly higher than that of the control group, while the lower esophageal sphincter pressure (LESP) and distal contractile integral (DCI) were significantly lower than those of the control group (P<0.05). The number of reflux duration ≥5 min, the total pH <4 time, the longest reflux duration, the number of reflux pH <4, the percentage of standing pH <4 time, and the percentage of lying pH <4 time were significantly higher in the observation group than in the control group (P<0.05).Conclusion:HREM has high application value in the evaluation of esophageal motor function in GERD, and it can accurately reflect the esophageal motor status related to GERD.
万方数据