The correlation between the increase of peripheral blood B cells and the recurrence of autoimmune encephalitis
Objective To analyze the correlation between peripheral blood lymphocyte subsets,especially B cells,and the relapse of autoimmune encephalitis(AE).Methods A retrospective analysis was conducted on patients with AE who were diagnosed and treated in Peking Union Medical College Hospital from January 2012 to January 2023.The clinical data including gender,age and changes in related indicators of CD19+B cells,CD16/56+NK cells,CD3+T cells,CD4+T cells,CD8+T cells,IgG,IgA,and IgM before and after recurrence were analyzed.Binary Logistic regression analysis was applied to the study of correlation between AE recurrence and gender,age,CD19+B cells,CD16/56+NK cells,CD3+T cells,CD4+T cells,CD8+T cells,IgG,IgA and IgM.The receiver operating characteristic(ROC)curves of the cells that affect AE recurrence(CD19+B cells,CD16/56+NK cells,CD3+T cells,CD4+T cells and CD8+T cells)were plotted separately.Results A total of 198 eligible AE patients were included,including 98 males and 100 females,aged(39.52± 17.91)years.Among these patients,78 cases had relapses,with a recurrence rate of 39.4％.The results of Logistic regression analysis showed that CD19+B cells(B=0.006,P＜0.001),CD16/564NK cells(B=0.004,P＜0.05),CD3+T cells(B=-0.011,P＜0.05),CD4+T cells(B=0.014,P＜0.05)and CD8+T cells(B=0.010,P＜0.05)were highly correlated with the relapse of AE.ROC curve analysis showed that CD19+B cells(area under the curve:0.833,P＜0.001,critical value:73.5/pl;sensitivity:69.2％,specificity:86.7％),CD3+T cells(area under the curve:0.784,P＜0.001),CD4+T cells(area under the curve:0.808,P＜0.001),and CD8+T cells(area under the curve:0.742,P＜0.001)all had a certain predictive value for AE relapse.Among all the indicators,the area under the curve of CD19+B cells was the largest,which had a higher value in predicting AE recurrence.Conclusion The increase in peripheral blood CD19+B cells has high predictive value for the relapse of AE.
NETL
NSTL
万方数据
维普
