Analysis of clinical characteristics of autoimmune encephalitis with antibodies against contactin-associated protein-like 2
Objective To explore the clinical characteristics of patients with antibodies against contactin-associated protein-like 2(CASPR2).Methods The clinical data of 24 patients with anti-CASPR2 encephalitis diagnosed at the First Affiliated Hospital of Zhengzhou University from January 2018 to December 2022 were retrospectively analyzed.According to the age of first onset,the patients were divided into early onset group(10 cases,onset age＜45 years)and late onset group(14 cases,onset age≥45 years).The clinical data including clinical manifestations,auxiliary examinations,and treatment response between these 2 groups were compared.Results Among the 24 patients,there were 13 cases with epilepsy,13 cases with cognitive decline,13 cases with mental disorders,14 cases with autonomic dysfunction,8 cases with peripheral nerve hyperexcitability,5 cases with Morvan syndrome,5 cases with unstable walking,and 8 cases with sleep disorders.Among the 10 cases of the early onset group,7 cases are females,and 8 cases showed epilepsy.The incidence rate of epilepsy in the early onset group was higher than that in the late onset group(5/14,Fisher exact probability,P=0.047).Among the 14 cases of the late onset group,6 cases are females,9 cases showed cognitive impairment and 8 cases presented with mental disorders.There were 6 cases with abnormal brain magnetic resonance imaging(MRI).The cerebrospinal fluid protein of the late onset group[0.37(0.29,0.58)g/L]was higher than that in the early onset group[0.22(0.16,0.30)g/L;Z=-2.667,P=0.008].The modified Rankin Scale(mRS)scores before and after treatment were 3.29+0.83 and 1.50(0.75,2.25),which were higher than those in the early onset group[mRS scores before and after treatment were 2.10+0.99 and 0(0,1.00),t=-3.188,P=0.004;Z=-2.335,P=0.020J.Conclusions There are various symptoms in patients with anti-CASPR2 encephalitis.The early onset patients are common in women,with a higher incidence of epilepsy.The late onset patients are common in males,with prominent manifestations of cognitive impairment and mental disorders,which have a greater impact on daily living abilities.And abnormal MRI findings are common,and the cerebrospinal fluid protein is higher in late onset patients.Anti-CASPR2 antibody may cause more severe immune damage to the nervous system in elderly patients.
EncephalitisAutoantibodiesAge of onsetEpilepsyPeripheral nerves
NETL
NSTL
万方数据
维普
