Four cases of COVID-19 associated Guillain-Barré syndrome
COVID-19 associated Guillain-Barré syndrome(GBS)caused by peripheral nerve damage after SARS-CoV-2 infection is one of the most common COVID-19 related nervous system inflammatory diseases,with high incidence of respiratory failure and mortality.Positive SARS-CoV-2 RNA in cerebrospinal fluid of COVID-19 associated GBS patients has been rarely reported.This paper reports 4 patients with COVID-19 associated GBS in China who developed neurological symptoms 4-15 days after fever and were confirmed SARS-CoV-2 infection.All patients presented with progressive weakness of both lower limbs,3 patients with autonomic dysfunction such as defecation and urination disorders,and 1 patient with polycranial neuritis and Miller-Fisher syndrome such as bilateral facial palsy,dysphagia,diplopia and ataxia.Nerve conduction velocity and F wave were abnormal in 3 patients,and motor conduction pathway was abnormal in 1 patient.Anti-ganglioside antibodies were tested in 3 patients,and GD1a-IgG was positive in 1 patient.All 4 patients underwent metagenomic next-generation sequencing examination in blood and cerebrospinal fluid.SARS-CoV-2 RNA was positive in blood and cerebrospinal fluid of 3 patients,and SARS-CoV-2 RNA was positive in cerebrospinal fluid of 1 patient.
NETL
NSTL
万方数据
维普
