CD20 is a classic marker expressed by B cells.However,recent studies have found that CD20 is also dimly expressed on a small subset of CD3+T cells,and the CD20+T cells play an important proinflammatory role in multiple sclerosis(MS).Anti-CD20 monoclonal antibodies selectively deplete CD20+T cells and effectively suppress inflammatory disease activity.Although CD20+T cells have received increasing attention,the understanding of these cells is currently still in its infancy.This article provides an overview of the current knowledge about advanced progress of CD20+T cells as well as their roles in MS.
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