CD20+T淋巴细胞在多发性硬化中的作用及机制研究
CD20+T cells in multiple sclerosis
薛龙星 1刘洪波1
作者信息
- 1. 郑州大学第一附属医院神经内科,郑州 450052
- 折叠
摘要
CD20是一种经典的B细胞标志物,但近年来有研究发现,除B细胞外,部分CD3+T淋巴细胞亚型也微弱表达CD20分子,并且在多发性硬化(MS)的发病机制中发挥重要的促炎作用,抗CD20药物选择性清除CD20+T细胞后,可有效抑制炎性疾病活动.虽然CD20+T细胞受到越来越多的关注,但目前人们对其的理解仍处于起步阶段,文中就该细胞亚群的最新研究进展及其在MS中的作用作一综述.
Abstract
CD20 is a classic marker expressed by B cells.However,recent studies have found that CD20 is also dimly expressed on a small subset of CD3+T cells,and the CD20+T cells play an important proinflammatory role in multiple sclerosis(MS).Anti-CD20 monoclonal antibodies selectively deplete CD20+T cells and effectively suppress inflammatory disease activity.Although CD20+T cells have received increasing attention,the understanding of these cells is currently still in its infancy.This article provides an overview of the current knowledge about advanced progress of CD20+T cells as well as their roles in MS.
关键词
多发性硬化/CD20+T细胞/B细胞/T细胞Key words
Multiple sclerosis/CD20+T cells/B cells/T cells引用本文复制引用
基金项目
国家自然科学基金联合基金(U2004128)
河南省科学技术攻关计划(U2004128)
出版年
2024
NETL
NSTL
万方数据