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自身免疫性小脑共济失调诊断专家共识

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自身免疫性小脑共济失调(ACA)包括副肿瘤性小脑共济失调、抗谷氨酸脱羧酶小脑共济失调、原发性自身免疫性小脑共济失调等多种类型,是散发性小脑共济失调重要的、可治的病因。抗小脑抗体检测对ACA的诊断具有重要意义。ACA的诊断需要综合考虑临床表现、脑脊液学、神经影像学、抗神经抗体与相关共病等诊断要素。为规范ACA的诊断,专家组基于研究证据与专家经验,制订ACA诊断标准共识,予以推荐。
Consensus on diagnostic criteria for autoimmune cerebellar ataxia
Autoimmune cerebellar ataxia(ACA)includes paraneoplastic cerebellar ataxia,anti-glutamic acid decarboxylase antibody-related cerebellar ataxia and primary autoimmune cerebellar ataxia,etc,and is an important and potentially treatable cause of sporadic cerebellar ataxia.Identification of anti-cerebellar antibodies is of great significance for ACA diagnosis.The diagnosis of ACA requires comprehensive consideration of clinical manifestations,results of cerebrospinal fluids and anti-neuronal antibody examinations,neuroimaging,and related comorbidities.In order to standardize the diagnosis of ACA,the expert panel developed and recommended the consensus on the ACA diagnosis criteria based on the comprehensive review of literatures and expert opinions.

Cerebellar ataxiaAutoimmunityParaneoplastic syndromes,nervous systemAnti-cerebellar antibodiesDiagnostic criteriaExpert consensus

中华医学会神经病学分会感染性疾病与脑脊液细胞学学组、中国罕见病联盟自身免疫性脑炎专业委员会、王佳伟、关鸿志

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首都医科大学附属北京同仁医院神经内科,北京100730

中国医学科学院北京协和医院神经科,北京100730

小脑共济失调 自身免疫 副肿瘤综合征,神经系统 抗小脑抗体 诊断标准 专家共识

2024

中华神经科杂志
中华医学会

中华神经科杂志

CSTPCD北大核心
影响因子:1.329
ISSN:1006-7876
年,卷(期):2024.57(8)