Metagenomic next-generation sequencing of cerebrospinal fluid assisting in the diagnosis of adult severe epidemic encephalitis B:a case report
The clinical manifestations of Japanese encephalitis virus infection are often acute encephalitis,and etiological diagnosis is a common diagnostic method.It is difficult to detect and isolate viruses clinically,and the types of pathogens detected are relatively limited.Metagenomics second-generation sequencing(mNGS)is a rapid and accurate molecular diagnostic method,which can improve the detection rate and types of pathogenic microorganisms.Pathogens uncommon in central nervous system infections can be detected.This paper reports a 27-year-old male patient with nausea and vomiting,high fever,disturbance of consciousness,and multiple organ failure as the main clinical manifestations.Japanese encephalitis virus was considered clinically,but etiological evidence was lacking.Japanese encephalitis virus was detected by cerebrospinal fluid mNGS,which greatly improved the accuracy of diagnosis of Japanese encephalitis virus infection.
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