Electro-clinical aspects of epilepsy with fixation-off sensitivity
Objective To summarize the clinical and electrophysiological characteristics of epilepsy patients with fixation-off sensitivity(FOS).Methods Using"fixation-off sensitivity"and"epilepsy"as search terms,data were retrieved from the Electroencephalogram Monitoring Center Database of Xijing Hospital,Air Force Military Medical University.Information was collected on epilepsy patients with FOS who were seen at the Xijing Hospital Electroencephalogram Monitoring Center from March 2019 to May 2023.A retrospective analysis of video electroencephalograms and clinical information was conducted,along with follow-up.Single factor analysis and multi-factor Logistic regression analysis were used to analyze the risk factors affecting the prognosis of the patients.Results A total of 78 patients met the inclusion criteria,including 43 females and 35 males;the age at first epilepsy onset was 12.00(8.00,15.25)years.Among these 78 patients,46 were diagnosed with genetic generalized epilepsy,11 with self-limited focal epilepy,9 with familial cortical myoclonic tremor with epilepsy,7 with developmental and epileptic encephalopathy,3 with symptomatic epilepsy,and 2 with progressive myoclonic epilepsy.The fixation-off induction trial most commonly triggered seizures in epilepsy with eyelid myoclonia(EEM)patients,with eyelid myoclonia being the most common type of seizure.Twenty-five epilepsy patients with FOS showed a positive photoparoxysmal response,of whom 6 experienced photo-convulsive response.Sixty-eight patients completed follow-up with comprehensive clinical data.At the last follow-up,45 patients had been free from tonic-clonic seizures for at least one year.A history of febrile seizures(OR=20.559,95％CI 2.179-193.997,P=0.008)and cognitive decline(OR=3.752,95％CI 1.118-12.588,P=0.032)were identified as risk factors for poor prognosis in epilepsy patients with FOS.The age of first epilepsy onset,the number of anti-seizure medications,and the intermittent photo stimulation trial results had no correlation with prognosis.Conclusions FOS is more common in female epilepsy patients and can be observed in both generalized and focal epilepsy syndromes.EEM patients are prone to seizures during fixation-off induction trial,and the most common type of seizures is eyelid myoclonus seizure.Patients with epilepsy with FOS who have a history of febrile seizures and cognitive impairment tend to have poor prognosis.
NETL
NSTL
万方数据
