A preliminary study on the application of brain sensing technology in the treatment of Parkinson's disease with deep brain stimulation of the subthalamic nucleus
Objective To preliminarily explore the application of Percept PC in the treatment of Parkinson's disease(PD)with deep brain stimulation(DBS)of the subthalamic nucleus(STN),and to compare the effect on initial programming with Lead-DBS imaging technology.Methods A retrospective study was conducted on 15 patients with primary PD who received STN-DBS at the Department of Neurosurgery,the First Medical Center of Chinese PLA General Hospital and the Neurosurgery Department of two other hospitals from January 2023 to September 2023.Among them,there were 5 cases in the Percept PC group and 10 cases in the Lead-DBS group.In the Percept PC group,the programmed contacts were chosen based on the monitored electrophysiological information,and the contacts with the highest local field potential(LFP)amplitude in the beta frequency band were used as the active contact in initial programming.In the Lead-DBS group,Lead-DBS imaging software was used to assist in choosing active contacts located in the targets and performing initial programming with the traditional method.We then observed the recording status of Percept PC and compared the initial programming of the two groups.Results In 5 patients in the Percept PC group,the Timeline function was turned on after surgery,and the LFP change of the micro-lesion effect was recorded in all case.The LFP fluctuations were observed through the Survey function and Streaming function.The clinical symptoms of all 5 patients were improved after determining the active stimulation contacts and currents.In initial programming,the programming time of the Percept PC group and the Lead-DBS group were 44.0±4.2 min and 63.9±6.2 min respectively;the median(Q,,Q3)number of adverse reactions during the test was 0(0,1)times and 2(1,3)times,and the differences were statistically significant(both P＜0.05).After turning on the device,the improvement rate of the score assessed based on the third part of the Unified Parkinson's Disease Rating Scale in the Percept PC group and the Lead-DBS group was(65.2±7.3)％and(75.4±18.7)％respectively;the median(Q,,Q3)reduction rate of equivalent dose of levodopa after surgery in the Percept PC group and the Lead-DBS group was 37.2％(7.1％,44.8％)and 28.9％(11.0％,42.5％)respectively,and the differences were not statistically significant(both P＞0.05).Conclusions The application of Percept PC in STN-DBS treatment of PD can effectively alleviate the clinical symptoms of patients by selecting programmed contacts through brain sensing function.Compared with Lead-DBS imaging technology-assisted programming,Percept PC is associated with shorter initial programming time and less occurrence of adverse reactions.
Parkinson diseaseDeep brain stimulationSubthalamic nucleusPerceptiveProgram control
万方数据
维普
