Clinical analysis of vagus nerve stimulation with low cervical single incision for the treatment of drug-resistant epilepsy
Objective To explore the safety and effectiveness of vagus nerve stimulation(VNS)with low cervical single incision in the treatment of drug-refractory epilepsy(DRE).Methods The clinical data of 78 DRE patients admitted to the Epilepsy Center of Qilu Hospital of Shandong University from June 2016 to May 2022 were retrospectively analyzed.Among them,57 cases underwent VNS through a low cervical single incision(single-incision VNS group),and 21 cases underwent VNS using traditional double incisions(double-incision VNS group).Postoperative outpatient or telephone follow-up was used to evaluate the surgical efficacy based on the control of epileptic seizures(including responder rate and seizure-free rate).The baseline characteristics,operation time,intraoperative blood loss,surgical efficacy and occurrence of postoperative complications were compared between the two groups of patients.Results There were no statistically significant differences between the single-incision VNS group and the double-incision VNS group in terms of age,gender,disease duration,epileptic seizure type,operation duration,or intraoperative blood loss(all P＞0.05).Comparing the two groups of patients,there were no statistically significant differences in the responder rate(x2=3.00)or seizure-free rate(x2=2.00)at 6,12,or 24 months after surgery(all P＞0.05).There was no statistically significant difference in the incidence of postoperative infection or poor healing of incision between the two groups(P＞0.05),but the incidence of transient hoarseness[1.8％(1/57)vs.14.3％(3/21)]or cough[3.5％(2/57)vs.19.0％(4/21)]was lower in the single-incision VNS group than in the double-incision group(both P＜0.05).Conclusion The surgical efficacy of single-incision VNS and double-incision VNS in the treatment of DRE are similar,but the former has a lower incidence of postoperative complications and can be used as an alternative VNS surgical method.
Drug resistant epilepsyVagus nerve stimulationTreatment outcomePosto-perative complicationsSingle incision
NETL
NSTL
万方数据
