The influence of aperiodic components on the analysis results of subthalamic nucleus local field potential in Parkinson's disease and its physiological significance
Objective To investigate the effect of aperiodic components on the results of local field potential(LFP)analysis of the subthalamic nucleus(STN)in patients with Parkinson's disease(PD)and its physiological significance in the assessment of motor symptoms.Methods A total of 27 PD patients with bilateral STN deep brain stimulation admitted to the Department of Functional Neurosurgery,Center for Neurosurgery,Zhujiang Hospital,Southern Medical University from February 2019 to September 2021 were retrospectively analyzed,of whom 21 were implanted with a classical pulse generator,and 6 were implanted with a novel pulse generator.Intraoperative and postoperative(only 6 patients implanted with the novel pulse generator)STN-LFP were collected from 1 to 6 months.Preoperative and postoperative limb motor symptoms were assessed using the third part of the Unified Parkinson's Disease Rating Scale,which included symptom scores for tremor,rigidity,and bradykinesia,as well as the sum of the three motor symptom scores.The neuronal power spectrum parameterization method was used to obtain the power values of the β-band of the original,fitted,original flat,and fitted flat spectra of the four spectra of the STN-LFP and the extracted aperiodic components(the aperiodic components,with the last two spectra obtained by removing the aperiodic components from the first two spectra,respectively),and to analyze the correlation between the aperiodic components and the motor symptoms.The patients with PD were classified into 2 motor subtypes:akinetic type(12 cases)and tremor-dominant type(15 cases).The receiver operating characteristic(ROC)curve was plotted and the area under the curve(AUC)was calculated to analyze the efficiency of the four spectrum identification of PD motor subtypes.The correlation between electrophysiological characteristics of different frequency bands of the 4 spectra and the motor symptoms was also analyzed.Results No correlation was found between the aperiodic component of intraoperative LFP and the preoperative limb motor symptom scores in 27 patients(all P＞0.05).Six patients implanted with the new pulse generator had a postoperative follow-up[M(IQR)]of 2.00(2.75)months,and none of the aperiodic components of postoperative LFP correlated with the postoperative limb motor symptom scores(all P＞0.05).ROC plot results showed that that the AUCs of the 4 spectra in the above order were 0.69,0.67,0.84 and 0.89,respectively.The classification efficacy of the fitted flat spectrum was better than that of the fitted spectrum(Z=1.86,P=0.033)and the original spectrum(Z=1.67,P=0.041),and the difference was statistically significant.The frequency-by-frequency power values of the four spectra of intraoperative and postoperative LFP were correlated with motor symptom scores in different frequency bands(all P＜0.05).Conclusion Despite no correlation between the aperiodic component itself and motor symptoms,it affects the results of STN-LFP spectral analysis and the classification efficacy of LFP-based determination of motor subtypes in patients with PD.
Parkinson diseaseSubthalamic nucleusLocal field potentialAperio-dic components
NETL
NSTL
万方数据
