Analysis of influencing factors of hypopituitarism after surgery for non-functioning pituitary neuroendocrine tumors
Objective To explore the influencing factors of hypopituitarism after surgery for non-functioning pituitary neuroendocrine tumors.Methods A retrospective analysis was conducted on the clinical data of non-functioning pituitary neuroendocrine tumors registered by the Department of Neurosurgery of the First Affiliated Hospital of Zhengzhou University from January 2019 to December 2022 in China's National Brain Tumor Registration Platform.A total of 1 210 patients were included.The patient's age,gender,clinicalsymptoms,preoperative and postoperative hormone levels,surgical method,surgical duration and follow-up time were collected.The patient's tumor volume,preoperative tumor apoplexy,Knosp grade,texture and extent of resection were collected.Univariate and multivariate logistic regression analyses(backward elimination method)were used to determine the influencing factors of postoperative hypopituitarism.Results Among 1 210 patients,617(51.0％)had hypopituitarism after surgery.The follow-up time[M(Q1,Q3)]of 1 210 patients was 6.5(3.0-11.2)months.The results of univariate logistic regression analysis showed that preoperative tumor apoplexy,preoperative hypopituitarism,tumor volume and operation duration were all influencing factors of postoperative hypopituitarism(all P＜0.05).The results of multivariate logistic regression analysis showed that preoperative tumor apoplexy(OR=1.96,95％CI:1.20-3.26,P=0.008)and preoperative hypopituitarism(OR=2.89,95％CI:2.09-4.05,P＜0.001)and larger tumor size(OR=1.02,95％CI:1.00-1.03,P=0.015)were risk factors for postoperative hypopituitarism.Conclusion Patients with non-functioning pituitary neuroendocrine tumors who have preoperative hypopituitarism,large tumor size,and tumor apoplexy have a higher risk of postoperative hypopituitarism.
Pituitary neoplasmsNeurosurgical proceduresHypopituitarismRoot cause analysis
NETL
NSTL
万方数据
