Coordinating tissue repair:molecular pathways controlling the function of harmful and repairing neutrophils
Neutrophils are the most abundant circulating white blood cells and play an indispensable role as first responders of damaged tissue and infected sites in the early inflammatory response of healing.Neutrophils provide immediate host defense by engulfing and destroying pathogens,releasing cytotoxic enzymes and metabolites,and spreading inflammatory networks.However,if left uncontrolled,these defense mechanisms can cause significant collateral damage.Focusing on the triggers of harmful neutrophil inflammation and immunomodulatory deficits,as well as grasping the specific drivers of harmful inflammation,is of great significance for recalibrating inflammation to promote endogenous tissue repair.This article,starting from the causes of neutrophil inflammation imbalance,elaborated the main mechanism of neutrophil-mediated tissue injury and related pathological manifestations,and highlighted the therapeutic targets with promising applications.
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