目的 探讨创面修复机制研究领域的热点和演化趋势.方法 该研究为文献计量学研究.检索Web of Science数据库核心合集中建库至2023年12月26日发表的符合入选标准的与创面修复机制研究相关的英文文献,统计年度发文量及其引文量并分析变化趋势.根据前述年度发文量再次检索Web of Science数据库核心合集中该领域发文增长迅速转折年份的前5年至2023年12月31日的相关文献,统计发文总量并计算年度发文增长率,并根据年度发文量趋势线预测2024年该领域发文量.采用CiteSpace 6.2.R4软件对第2次检索文献进行可视化分析,包括来源期刊、引用文献及关键词情况,探讨创面修复机制研究现状和热点的演变过程.结果 第1次检索共获取3 992篇创面修复机制研究相关文献,其中2015-2023年,年度发文量及其引文量均增加迅速.第2次检索时限设置为2011年1月1日-2023年12月31日,该时段共发文3 206篇,平均年度发文增长率为13.30％,根据该阶段的发文趋势线预测2024年该领域发文量可达500篇.第2次检索文献发表在717种期刊上,发文量排前10位的期刊[占总发文量的18.75％(601/3 206)]的研究方向主要为创伤、分子、中药药理及干细胞,主要出版国家为英国、美国等,影响因子＞5的期刊有7本,属于中国科学院分区Q1区或Q2区的期刊有6本.第2次检索文献的引用文献的关键词共形成906个节点及9大聚类(Q=0.64,S=0.82).第2次检索文献的引用文献在2006-2015年期间的主要聚类为#2基质金属蛋白酶和#3转化生长因子β1,在2016-2023年期间的主要聚类为#1巨噬细胞极化、#4间充质干细胞、#6抗菌、#7植物提取.其中,2021-2023年期间,第2次检索文献的引用文献的聚类#1巨噬细胞极化、#4间充质干细胞、#6抗菌和#7植物提取的共现关系最为密切.对被引值、中介中心值及Sigma值排前5位的第2次检索文献的引用文献的分析显示,巨噬细胞及炎症调控对创面修复的影响、成纤维细胞对创面修复的影响以及生长因子和细胞因子对创面修复的影响是主要研究方向.第2次检索文献的关键词共形成636个节点,7个聚类:#0抗菌、#1间充质干细胞、#2细胞迁移、#3创面修复、#4外泌体、#5负压伤口治疗及#6糖尿病足溃疡(Q=0.59,S=0.80).第2次检索文献在2016-2023年主要聚集于聚类#0抗菌、#1间充质干细胞和#4外泌体,在2015年前主要聚集于聚类#2细胞迁移和#3创面修复.第2次检索文献的关键词共形成110个突现关键词(以下简称突现词),突现强度排前10位的突现词依次为小鼠、基因表达、皮肤损伤、上皮细胞、信号通路、生物材料、外泌体、分子对接、水凝胶、巨噬细胞极化,其开始年和结束年的时限均不同.其中2021-2023年的高强度突现词为水凝胶(属于聚类#0抗菌)、外泌体(属于聚类#1间充质干细胞)、分子对接(属于聚类#0抗菌)、巨噬细胞极化(属于聚类#0抗菌).结论 未来,创面修复机制研究的发展仍会处于稳步阶段;该领域研究热点已经从生长因子及创面修复生理过渡到了抗菌及干细胞方向;该领域的未来研究方向可能为利用分子对接技术和网络药理学筛查促创面修复的药物并研究其深层机制、外泌体对巨噬细胞极化的调控以及水凝胶通过抗菌功效促进创面愈合的机制.
Visualized analysis of research hotspots and evolutionary trends in the field of wound repair mechanism research
Objective To explore the research hotspots and evolutionary trends in the field of wound repair mechanism research.Methods This study was a bibliometric analysis study.English literature related to wound repair mechanism published in the core collection of Web of Science database from the establishment of the database to December 26th,2023 that met the inclusion criteria were retrieved.The annual number of publications and their citations were counted,and the change trend was analyzed.Based on the aforementioned annual publication volume,the relevant literature in the core collection of Web of Science database in this field from the first 5 years when the publication growth in this field was rapidly turning,to December 31st,2023 was searched again,and the total number of publications was recorded and annual growth rate of published literature was calculated;and based on the trend line of annual publication volume,the publication volume in this field in 2024 was predicted.The CiteSpace 6.2.R4 software was used for visualized analysis of the literature from the second retrieval,including the source journals,the cited literature,and the keywords,to discuss the current research status and the evolution of hotspots of wound repair mechanism.Results The first search retrieved a total of 3 992 literature related to the research on wound repair mechanisms,among which the annual number of publications and their citations increased rapidly from 2015 to 2023.The time limit for the second retrieval was set to be from January 1st,2011 to December 31st,2023,during which a total of 3 206 literature was published,with an average annual growth rate of 13.30％.According to the publication trend line at this stage,it was predicted that the number of publications in this field will reach 500 in 2024.The literature from the second retrieval was published in 717 journals.The research directions of the top 10 journals with the most published literature(accounting for 18.75％(601/3 206)of the total number of publications)mainly focused on trauma,molecules,pharmacology of Chinese medicine,and stem cells,with the United Kingdom and the United States,etc.as the main publishing countries.There were 7 journals with impact factors＞5 and 6 journals belonging to the Q1 or Q2 areas of the Chinese Academy of Sciences.There were 906 nodes and 9 large clusters for the keywords of cited literature of literature from the second retrieval(Q=0.64,S=0.82).The main clusters of cited literature of literature from the second retrieval were #2 matrix metalloproteinases and #3 transforming growth factor β1 from 2006 to 2015,#1 macrophage polarization,#4 mesenchymal stem cells,#6 antibacterial,and #7 plant extraction from 2016 to 2023.During 2021-2023,the main clusters of cited literature of literature from the second retrieval being #1 macrophage polarization,#4 mesenchymal stem cells,#6 antibacterial,and #7 plant extraction had the most closely related co-occurrence.The analysis of the top 5 cited literature of literature from the second retrieval with high citation value,high centrality value,and high Sigma value showed that the main research directions were the influence of macrophages and inflammation regulation on wound repair,the influence of fibroblasts on wound repair,and the influence of growth factors and cytokines on wound repair.The keywords of literature from the second retrieval formed 636 nodes and 7 clusters,that being #0 antibacterial,#1 mesenchymal stem cells,#2 cell migration,#3 wound repair,#4 exosomes,#5 negative pressure wound treatment,and #6 diabetic foot ulcer(Q=0.59,S=0.80).For the literature from the second retrieval,the main clusters from 2016 to 2023 were #0 antibacterial,#1 mesenchymal stem cells,and #4 exosomes,and the main clusters before 2015 were #2 cell migration and #3 wound repair.A total of 110 burst keywords(hereinafter referred to as burst words)were formed for the keywords of literature from the second retrieval,and the top 10 burst words in terms of intensity were mouse,gene expression,skin injury,epithelial cells,signaling pathways,biomaterials,exosomes,molecular docking,hydrogels,and macrophage polarization,with different start and end time periods.Among them,the high-intensity burst words from 2021 to 2023 were hydrogel(belonging to cluster #0 antibacterial),exosome(belonging to cluster #1 mesenchymal stem cells),molecular docking(belonging to cluster #0 antibacterial),and macrophage polarization(belonging to cluster #0 antibacterial).Conclusions In the future,the development of wound repair mechanism research will still be at a steady phase.The research hotspots in this field have shifted from growth factors and wound repair physiology to antibacterial and stem cells.Future research directions in this field may include using molecular docking technology and network pharmacology to screen drugs that promote wound repair and study their underlying mechanisms,the regulation of macrophage polarization by exosomes,and the mechanism by which hydrogels promote wound healing through antibacterial effects.
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