脂肪因子在糖尿病外周血管病变中的作用研究进展
Research advances on the role of adipokines in diabetic peripheral arterial diseases
鲁珽 1刘啊敏 1金启辉 2张玲3
作者信息
- 1. 浙江大学医学院附属第二医院基础和转化研究中心,杭州 310009
- 2. 浙江大学医学院附属第二医院老年医学科,杭州 310009
- 3. 浙江中医药大学生命科学学院,杭州 310053
- 折叠
摘要
外周血管病变是糖尿病常见的并发症之一.目前尚未完全明确糖尿病外周血管病变的发病机制,且该病缺少有效的治疗手段和药物.脂肪因子对糖尿病及其并发症的发生发展有着深刻的影响,直接或间接地参与了糖尿病外周血管病变的进程.不同的脂肪因子或抑制血管病变的发生,或促进其发生,机制复杂且尚存在许多争议.脂肪因子有望成为治疗糖尿病外周血管病变的新靶点,值得进一步深入研究.该文主要对一些常见的脂肪因子和新型脂肪因子与糖尿病外周血管病变的关系进行综述,旨在为糖尿病外周血管病变的临床治疗提供新方法.
Abstract
Peripheral arterial disease is one of the common complications of diabetes.At present,the pathogenesis of diabetic peripheral arterial diseases is not completely clear,and there is a lack of effective treatment methods and drugs.Adipokines have profound impact on the occurrence and development of diabetes mellitus and its complications,and are directly or indirectly involved in the progression of diabetic peripheral arterial diseases.Different adipokines may inhibit or promote the occurrence of vascular diseases with the mechanisms that are complex and controversial.Adipokines are expected to be a new target for the treatment of diabetic peripheral arterial disease,which is worthy of further study.This article mainly reviews the relationship between some common adipokines and new adipokines and diabetic vascular disease,aiming to provide new methods for the clinical treatment of diabetic peripheral arterial disease.
关键词
糖尿病/外周血管疾病/脂肪因子类/药物相互作用Key words
Diabetes mellitus/Peripheral vascular diseases/Adipokines/Drug interactions引用本文复制引用
基金项目
浙江省公益技术研究计划实验动物项目(GD21C040018)
出版年
2024
NETL
NSTL
万方数据