缺氧与炎症在创面愈合中扮演的角色
Roles of hypoxia and inflammation in wound healing
魏在荣 1张演基 1王达利1
作者信息
- 1. 遵义医科大学附属医院烧伤整形外科,遵义 563003
- 折叠
摘要
创面愈合是一个复杂的生物学过程,缺氧和炎症是启动创面愈合和影响创面愈合进程的2个关键因素.缺氧诱导因子1α(HIF-1α)和核因子κB是缺氧和炎症环境下的重要调控因子,缺氧和炎症之间的相互作用本质上由HIF-1α和核因子κB信号通路所介导,二者失调导致的HIF-1α或核因子κB信号通路的异常表达均会影响创面微环境,导致创面异常愈合.该文讨论了缺氧和炎症对创面愈合的影响,强调了缺氧和炎症之间的相互协作对创面愈合的作用,以及二者失调对创面愈合质量的影响,并对目前缺氧和炎症信号通路的干预策略进行总结,同时对未来创面的治疗进行展望.
Abstract
Wound healing is a complex biological process.Hypoxia and inflammation are the two key factors that initiate wound healing and affect the wound healing process.Hypoxia-inducible factor-1α(HIF-1α)and nuclear factor κB are the important regulators of hypoxia and inflammation.The interaction between hypoxia and inflammation is essentially mediated by HIF-1α and nuclear factor κB signaling pathways.The abnormal expression of HIF-1α or nuclear factor κB signaling pathway caused by the imbalance of hypoxia and inflammation will affect the wound microenvironment and lead to abnormal wound healing.This paper discussed the effects of hypoxia and inflammation on wound healing,emphasized the role of cooperation between hypoxia and inflammation on wound healing and the effect of their imbalance on the quality of wound healing,summarized the current intervention strategies of hypoxia and inflammation signaling pathways,and prospected the treatment of wound in the future.
关键词
伤口愈合/炎症/低氧/缺氧诱导因子1Key words
Wound healing/Inflammation/Hypoxia/Hypoxia-inducible factor 1引用本文复制引用
基金项目
国家自然科学基金地区科学基金(82360445)
省部共建协同创新中心项目(教科技厅函[2020]39号)
遵义市科技计划(2021-3)
贵州茅台医院科研与人才培养资金项目(mtyk2022-13)
出版年
2024
NETL
NSTL
万方数据