Roles of hypoxia and inflammation in wound healing
Wound healing is a complex biological process.Hypoxia and inflammation are the two key factors that initiate wound healing and affect the wound healing process.Hypoxia-inducible factor-1α(HIF-1α)and nuclear factor κB are the important regulators of hypoxia and inflammation.The interaction between hypoxia and inflammation is essentially mediated by HIF-1α and nuclear factor κB signaling pathways.The abnormal expression of HIF-1α or nuclear factor κB signaling pathway caused by the imbalance of hypoxia and inflammation will affect the wound microenvironment and lead to abnormal wound healing.This paper discussed the effects of hypoxia and inflammation on wound healing,emphasized the role of cooperation between hypoxia and inflammation on wound healing and the effect of their imbalance on the quality of wound healing,summarized the current intervention strategies of hypoxia and inflammation signaling pathways,and prospected the treatment of wound in the future.
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