摘要
瘢痕疙瘩是一种常见的皮肤疾病,其发生机制尚不完全清楚,但已有证据表明,多种因素如遗传、种族、年龄、性别、激素、感染、免疫、氧化应激等都可能与瘢痕疙瘩的发生相关.代谢重塑及蛋白酰化修饰作为2种重要的生物学过程,在多种皮肤相关疾病中发挥着重要作用.基于此,该文综述代谢重塑及蛋白酰化修饰在瘢痕疙瘩中的作用及这2种生物学过程的相互关系,并探讨靶向这2种生物学过程在预防和治疗瘢痕疙瘩中的应用前景.
Abstract
Keloid is a common skin disease,and the mechanism of its occurrence is not fully understood.There is evidence to show that multiple factors such as genetics,race,age,gender,hormones,infection,immunity,and oxidative stress,etc.may be related to the occurrence of keloids.Metabolic remodeling and protein acylation modification,as two important biological processes,play important roles in various skin related diseases.Based on this,this article reviews the roles of metabolic remodeling and protein acylation modification in keloids and the interrelationship between the two biological processes,and explores the application prospects of targeting the two biological processes in the prevention and treatment of keloids.
基金项目
山东省自然科学基金面上项目(ZR 2021MH338)
NETL
NSTL
万方数据