Research advances on the non-coding RNAs carried by exosomes as competitive endogenous RNAs involved in wound healing
In recent years,non-coding RNAs(ncRNAs)carried by exosomes have been shown to play an important regulatory role in multiple stages of wound healing.Exosomes can transport ncRNAs to different target cells or tissue and regulate the expression of target genes and downstream molecules.The proposed competing endogenous RNA(ceRNA)hypothesis suggests that RNAs can build a more sophisticated and complex gene regulatory network by competing for common response elements.Therefore,this review focuses on the long ncRNAs and circular RNAs carried by exosomes,discusses their regulatory roles as ceRNAs in the stages of inflammation,cell proliferation,and tissue remodeling in wound repair,respectively,and summarizes the feasibility of ncRNAs carried by exosomes as cell-free therapy,in order to provide a theoretical basis for clinical treatment of wounds.
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