原位细胞电纺技术及其在创面修复中的应用研究进展
Research advances on in-situ cell electrospinning and its application in wound repair
刘华振 1张毅 2高闯 2陆春祥 2郭子龙 2孙文彬 2肖仕初 3刘媛媛1
作者信息
- 1. 上海大学医学院,上海 200444
- 2. 上海大学机电工程及自动化学院,上海 200444
- 3. 海军军医大学第一附属医院烧伤外科,上海 200433
- 折叠
摘要
目前在临床上实现创面的便捷快速修复的策略有限.近年来,在原位静电纺丝(IS-E)技术的基础上,发展出了原位细胞电纺(IS-CE)技术,其通过将活细胞封装在微纳米纤维中,原位构建出活体纤维组织支架,并在创面修复的应用中取得一定进展,但该技术依然存在细胞存活率低和纤维稳定性差等局限.该文综述了 IS-E和IS-CE技术的现状以及IS-CE技术在创面修复中的应用,此外,重点探讨了将IS-CE技术应用于创面治疗的优势、局限性和改进方法,以期为IS-CE技术在组织工程和创面修复中的应用提供参考依据.
Abstract
Currently,there are limited strategies for convenient and rapid wound repair in clinical practice.In recent years,in-situ cell electrospinning(IS-CE)technology,developed from in-situ electrospinning(IS-E)technology,has emerged.IS-CE technology involves encapsulating living cells within micro-nanofibers to construct living fibrous tissue scaffolds in situ,making some progress in wound repair applications.However,this technology still faces limitations such as low cell survival rate and poor fiber stability.This article provides a comprehensive review on the current status of both IS-E and IS-CE technologies,as well as the application of IS-CE technology in wound repair.In addition,the advantages,limitations,and improvement methods of IS-CE technology applied in wound treatment are emphatically discussed,aiming to provide insights for its application in tissue engineering and wound repair.
关键词
纳米纤维/组织支架/组织工程/原位细胞电纺/创面修复Key words
Nanofibers/Tissue scaffolds/Tissue engineering/In-situ cell electrospinning/Wound repair引用本文复制引用
基金项目
国家自然科学基金面上项目(82372513)
国家自然科学基金面上项目(61973206)
上海大学跨学科新医科研究生创新基金()
出版年
2024
NETL
NSTL
万方数据