Research advances on the role of pyroptosis in diabetic wound healing
Diabetic wound is a complication of diabetes,which is difficult to heal and easy to turn into chronic wound.Compared with ordinary wound healing,diabetic wounds stay in the inflammatory stage and can not enter the proliferative stage.This is because the proportion of pro-inflammatory cytokines increases,leading to the imbalance of inflammatory cells and the accumulation of a large number of inflammatory factors.The production and release of inflammatory factors is closely related to pyroptosis.Pyroptosis is a kind of programmed death mode of inflammatory cells.Mediated by inflammasome,pyroptosis is transduced through typical and atypical inflammasome signaling pathways,resulting in the formation of pores on the cell membrane and inducing cell death.In this process,a large number of pro-inflammatory cytokines are released to maintain the inflammatory environment of wounds,hindering the development of diabetic wounds to the proliferative stage and remodeling stage,thus inhibiting the healing of diabetic wounds.This article reviews the mechanism of pyroptosis and its effect on diabetic wounds,the potential significance of inhibiting pyroptosis in the treatment of diabetic wounds,and the existing problems.
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