Continuous inflammatory response and repeated tissue damage lead to a chronic inflammatory state that is an important pathological feature of chronic refractory wounds,and plays an important pathogenic role in the occurrence and development of chronic refractory wounds.Multiple types of programmed cell death can release damage-associated molecular patterns,and trigger or induce sustained inflammatory responses,leading to dysregulated tissue repair.This review will outline the known role of programmed cell death in the inflammatory response of chronic refractory wounds from the perspective of generating damage-associated molecular patterns,and explore possible research directions on the role and mechanism of programmed cell death in chronic refractory wounds.
维普
万方数据