摘要
腺病毒是一种双链DNA病毒,可引起呼吸道、胃肠道、眼睛、肾脏和其他器官感染,轻度腺病毒感染一般是自限性疾病,但部分患者进展为高热、呼吸困难、呼吸衰竭等严重感染或播散性感染疾病.目前尚无特异性抗腺病毒药物上市,本文总结了西多福韦在腺病毒感染临床治疗中的应用,从成人重症腺病毒感染、儿童腺病毒感染、器官移植患者感染及衍生物4个方面展开阐述.总体而言,西多福韦在治疗腺病毒重症感染中有一定作用,但多数研究样本量偏少且缺少前瞻性队列研究,今后开展相关临床研究时需重点考虑.另外基于西多福韦开发衍生化合物或寻找类似药物,降低其肾毒性,也是未来研究关注的重点.
Abstract
Adenovirus is a group of double-stranded DNA virus,which can cause infections of respiratory tract,gastrointestinal tract,eye,kidney and other organs.Adenovirus infection is generally self-limited disease,while in some patients progresses to high fever,dyspnea,respiratory failure and other serious infection or disseminated infection.At present,there are no approved drug for human adenovirus infection.This review summarized the clinical application of cidofovir in the treatment of adenovirus infection,including adult severe adenovirus infection,child adenovirus infection,organ transplantation infection,derivative compounds.In general,cidofovir has a certain role in the treatment of severe adenovirus infection,but most studies have small sample sizes and lack prospective cohort studies,which should be considered in future clinical studies.In addition,the development of derivative compounds or similar drugs based on cidofovir to reduce its renal toxicity is also the focus of future research.
基金项目
院管课题(2021-XZYG-B11)
四川省科技厅重点研发项目(2019YFS0367)
NETL
NSTL
万方数据