摘要
目的 分析我国2016-2021年儿童病毒性心肌炎(viral myocarditis,VMC)的流行特征及疾病负担,为我国儿童VMC的诊疗及防控提供基础参考数据.方法 通过福棠儿童医学发展中心收集我国2016-2021年23个省份(直辖市)27家儿童医院或妇幼保健院中的VMC住院患儿病历首页信息,对我国儿童VMC流行病学、死亡情况及疾病负担进行描述性统计分析.结果 本研究共纳入7 647 599例住院患儿,其中VMC患儿1 646例.2016-2021年VMC住院患儿人数年度分布分别为173例、227例、313例、301例、295例和337例,住院占比分别为14.9/10万人、17.9/10万人、23.0/10万人、20.5/10万人、26.5/10万人和26.4/10万人;VMC患儿的住院占比总体呈逐年升高趋势(P＜0.001).不同年龄组患儿的住院占比呈现随发病年龄增大而升高的趋势(P＜0.001),12-≤ 18岁年龄组患儿的住院占比最高.西北地区的住院患儿人数(625例,38.46％)及住院占比(64.9/10万人)最高,华东地区次之.本研究中共有68例死亡患儿,VMC住院患儿病死率为4.13％,不同性别、年龄组、季节、年份的VMC住院患儿病死率无明显统计学差异.所有VMC患儿住院时长中位数为10天(IQR 6,21),住院费用中位数为11 842.30元(IQR 6 969.22,19 714.78).其中,死亡患儿住院时长中位数仅1天(IQR 1,3),而住院费用中位数可达8 874.03元(IQR 5 277.94,56 151.59),VMC患儿死亡发生迅速,造成严重的疾病负担.结论 VMC患儿住院占比呈逐年升高趋势,12-≤18岁年龄组患儿住院占比最高;VMC住院患儿总体病死率可达4.13％,且死亡发生迅速.
Abstract
Objective This study aimed to provide basic data for the prevention,diagnosis and treatment of pediatric viral myocarditis(VMC)in China through analyzing the epidemic characteristics and disease burden of pediatric inpatients with VMC from 2016 to 2021.Methods We performed a descriptive statistical analysis to the age,genders,seasons,regions and hospitalization cost and days of pediatric VMC inpatients and the death.All of the information was obtained from 27 Children's hospitals or Maternal and Child Health hospitals of 23 provinces of China from 2016 to 2021.Results A total of 7 647 599 cases including 1 646 VMC inpatients were admitted into our study.The annual numbers of hospitalizations were 173,227,313,301,295 and 337,with the hospitalized constituent ratios being 14.9/100 000,17.9/100 000,23.0/100 000,20.5/100 000,26.5/100 000 and 26.4/100 000 from 2016 to 2021.In recent 6 years,the proportion of VMC hospitalizations had increased yearly(P＜0.001),and had associated with the onset age(P＜0.001).Aged 12-≤18 years owned the highest hospitalized constituent ratio.The Northeast of China owned the largest number of VMC inpatients,and the East second to it.Among the 1 646 VMC children,there were 68 deaths,with the hospitalized case fatality rate of 4.13％.There were no significant differences between genders,age,seasons,years and fatality rate of VMC inpatients.For the diseases burden,the median of hospitalization days of all VMC inpatients was 10 days(IQR 6,21),and the median of hospitalization cost was 1 1 842.3 RMB(IQR 6 969.22,19 714.78).The median of hospitalization days of deceased VMC children was only 1 day(IQR 1,3),the median cost could be 8 874.03 RMB(IQR 5277.94,5 6 151.59).Conclusions In this study,we found that proportion of hospitalization of VMC children increased year by year,adolescence might be a risk factor of VMC.The fatality of VMC inpatients could be up to 4.13％,and the death led to a huge economic burden of society,family and individuals.
基金项目
国家自然科学基金(82172245)
国家重点研发计划(2018ZX10201002-003-009)
北京市自然科学基金-海淀原始创新联合基金(L192014)
中国医科院医学与健康科技创新工程项目(2019-I2M-5-026)
北京市卫生健康委改革与发展项目()
NETL
NSTL
万方数据