摘要
目的 对基于全国多中心的住院患儿腺病毒肠炎流行病学特征进行分析报告.方法 基于福棠更新病历(FUTURE)数据库,收集了 2016年1月至2021年12月来自我国22家三级儿童医院因腺病毒肠炎住院的患儿病历首页信息,分析其流行特征和疾病负担.结果 在本数据库中,1 638名儿童因腺病毒肠炎住院,占同年龄段总住院人数的0.03％(1 638/5 465 249),占因腹泻住院人数的2.88％(1 638/56 859).男女比例为1.47:1.男性在各年龄段、年份和居住地均多于女性.因腺病毒肠炎住院的儿童中,7月龄～2岁住院人数占比最多,为77.41％,同时,占同年龄段总住院人数的比例最大,为0.070％.此外,2016-2021年住院人数逐年增加,且夏秋季(7～10月份)住院人数明显增加.2/3的腺病毒肠炎患儿无明显肠外合并症,1/5的患者会出现肺炎、急性支气管炎等呼吸系统合并症.腺病毒肠炎患儿住院时长中位数为5天(IQR 3.75～6.00),住院费用中位数为4 582.56元(IQR 3 261.52～6 256.87).结论 本研究表明腺病毒肠炎是我国住院儿童腹泻的重要病因,其中7月龄～2岁为住院的主体人群,男性住院率显著高于女性,7～10月份为住院高峰时间,多数患儿无肠外合并症.
Abstract
Objective This report analyzed the epidemiological characteristics of adenovirus enteritis in hospitalized children based on data from a nationwide multicenter study.Methods We analyzed patient admission records of children hospitalized for adenoviral enteritis from the FUTang Update medical Records(FUTURE)database.Data were collected from 22 tertiary pediatric hospitals between January 2016 and December 2021.The study focused on identifying epidemiological trends and assessing the disease burden.Results A total of 1 638 children were hospitalized for adenovirus gastroenteritis,accounting for 0.03％(1 638/5 465 249)of all hospitalizations in this age group and 2.88％(1 638/56 859)of diarrhea-related hospitalizations.The male-to-female ratio was 1.47:1,with more males affected across all age groups,years,and regions.The majority of hospitalizations(77.41％)occurred among children aged 7 months to 2 years,who also represented the highest proportion(0.070％)of hospitalizations within their age group.Additionally,the number of hospitalizations increased annually from 2016 to 2021,with a noticeable rise in admissions during the summer and autumn months(July-October).Two-thirds of the patients had no significant extraintestinal comorbidities,while approximately one-fifth developed respiratory comorbidities such as pneumonia or acute bronchitis.The median length of hospital stay was 5 days(IQR 3.75-6),and the median hospitalization cost was 4 582.56 RMB(IQR 3 261.52-6 256.87).Conclusions This study highlights adenovirus gastroenteritis as a significant cause of diarrhea-related hospitalizations in children in China,particularly among those aged 7 months to 2 years.Hospitalization rates were notably higher in males,with a peak in admissions during July to October.Most children experienced no extraintestinal comorbidities.
维普
万方数据