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非编码核酸在病毒感染中的调控作用及对病毒防控的启示

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非编码核酸(ncRNA)在病毒感染过程中发挥着多层次、多维度的调控作用,涉及病毒复制、宿主免疫反应、细胞死亡及表观遗传调控等多个方面.miRNA、lncRNA和circRNA等不同类型的ncRNA通过多种机制调节宿主基因表达,影响病毒的致病性和传播能力.本文系统综述了 ncRNA在病毒感染中的最新研究进展,重点探讨了其调控机制、在特定病毒感染中的作用特点及其作为抗病毒治疗靶点的潜力.通过系统归纳相关研究,揭示了 ncRNA在病毒与宿主互作中的复杂网络,并提出了未来研究的潜在方向.此外,结合公共卫生与病毒传播的关联,以及卫生管理策略,强调了对ncRNA研究在公共卫生领域的重要性.
Regulatory role of non-coding RNA in viral infections:insights for virus prevention and control
Non-coding RNAs(ncRNAs)play a multi-level and multidimensional regulatory role in the process of viral infection,involving multiple aspects such as virus replication,host immune response,cell death,and epigenetic regulation.Different types of ncRNAs such as miRNA,lncRNA,and circRNA regulate host gene expression through various mechanisms,affecting the pathogenicity and transmission ability of viruses.This article systematically reviews the latest research progress of ncRNA in viral infections,focusing on its regulatory mechanisms,characteristics of its role in specific viral infections,and its potential as a target for antiviral therapy.By systematically summarizing relevant research,the complex network of ncRNA in virus host interaction has been revealed,and potential directions for future research have been proposed.In addition,combining the relationship between public health and virus transmission,as well as health management strategies,the importance of ncRNA research in the field of public health was emphasized.

Non-coding RNAVirusRegulatory mechanismTherapyPublic Health

张清、陶龙、马琳

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山东省第二人民医院,济南 250000

山东省精神卫生中心,济南 250000

非编码核酸 病毒 调控机制 治疗 公共卫生

2024

中华实验和临床病毒学杂志
中华医学会

中华实验和临床病毒学杂志

CSTPCD
影响因子:0.718
ISSN:1003-9279
年,卷(期):2024.38(6)