FXYD3蛋白在肝门胆管癌组织的表达及其临床意义
Expression and clinical significance of FXYD3 protein in hilar cholangiocarcinoma
马焕先 1高丽杰 1李崇辉 1周宁新2
作者信息
- 1. 100853北京,解放军总医院肝胆外科
- 2. 第二炮兵总医院肝胆胃肠病研究所
- 折叠
摘要
目的 探讨FXYD3蛋白组在肝门胆管癌组织的表达及其与临床病理学特征的关系.方法 采用免疫组织化学链酶亲和素-生物素-过氧化物酶复合物(SABC)法检测43例肝门胆管癌及相应癌旁组织中FXYD3蛋白的表达,分析FXYD3表达与肿瘤临床病理学特征的关系.结果 胆管癌组FXYD3蛋白表达阳性率为67.44％( 29/43)显著高于癌旁组32.56％( 14/43,P＜0.01),且前者的FXYD3蛋白表达与其组织分化程度明显相关(P＜0.01),与患者年龄、性别、肿瘤TNM分期及糖链抗原(CA19-9)的表达无明显相关(P＞0.05).结论 FXYD3蛋白表达与肝门胆管癌组织分化程度密切相关,可能在肿瘤细胞初始转化及发生发展过程中起重要作用.
Abstract
Objective To investigate the expression of FXYD3 protein in hilar cholangiocarcinoma and the relationship of FXYD3 protein expression with the biological characteristics of hilar cholangiocarcinoma cells.Methods Strept avidin-biotin complex (SABC) immunohistochemical method was used to detect the expression of FXYD3 protein in 43 hilar cholangiocarcinoma and paraneoplastic tissues respectively.The relationship of FXYD3 protein expression with the biological characteristics of hilar cholangiocarcinoma cells was analyzed.Results The positive expression rate of FXYD3 protein in hilar cholangiocarcinoma was 67.44％ (29/43),significantly higher than that of 32.56％ ( 14/43 ) in paraneoplastic tissue (P＜ 0.01 ).FXYD3 protein expression was significantly correlated with the histological classification (P ＜ 0.01 ),but not with patient' s age,gender,TNM stage and casbohydrate antigen19-9 (CA19-9) expression (P ＞ 0.05).Conclusion FXYD3 protein expression was significantly correlated with the histological classification,suggesting it may be a very critical factor in primary cell transformation and progress of hilar cholangiocarcinoma.
关键词
肝门胆管癌/FXYD3蛋白/生物学Key words
Hilar cholangiocarcinoma/FXYD3 protein/Biology引用本文复制引用
出版年
2012
NETL
NSTL
维普
万方数据