Research progress on the protective effect and mechanism of cordycepin in ischemia-reperfusion injury
Ischemia-reperfusion injury is a common clinical challenge in surgery,which has a significant impact on the prognosis of patients.It is a complex,multi-factor,multi-cell intertwined pathological process.Many scholars had explored its mechanism,but the drugs used in clinical practice still need to be further developed.Cordycepin (3'-deoxyadenosine),a natural derivative of adenosine,is one of the important active ingredients in Cordyceps militaris.It has many pharmacological activities such as anti-inflammatory,anti-aging,anti-tumor,immune regulation and metabolism.In this review,we summarized the protective effects and mechanism of cordycepin in ischemia-reperfusion injury in recent years.
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