摘要
胰腺癌是一种高度恶性的消化系统肿瘤,5年生存率仅有9％.近年来,胰腺癌发病率和死亡率呈现持续上升趋势,发病群体也将出现年轻化趋势.筛查胰腺癌高危人群可能是提高胰腺癌治疗效果及改善预后的有效措施.液体活检作为一种无创检测手段,通过检测循环肿瘤细胞、循环肿瘤基因、外泌体等以实现肿瘤的辅助诊断,具有易于获得和允许实时监测肿瘤演变等优势.本文聚焦于胰腺癌的危险因素以及基于胰腺癌不同样本类型的辅助诊断技术和新型标志物.
Abstract
Pancreatic cancer is a highly malignant digestive system tumor with a mere 9％5-year survival rate.In recent years,an alarming upward trajectory in both the incidence and mortality rates of pancreatic cancer appears,with a noticeable trend toward affecting a younger population.Screening high-risk individuals emerges as an effective measure to enhance therapeutic outcomes and patient prognosis.Liquid biopsy,as a non-invasive detection method,proves invaluable in identifying circulating tumor cells,circulating tumor genes,exosomes,and more,facilitating auxiliary tumor diagnosis.Liquid biopsy stands out due to its accessibility and capability for real-time monitoring of tumor evolution.This article aims to provide a comprehensive overview of the risk factors associated with pancreatic cancer,coupled with in-sights into auxiliary diagnostic techniques and novel markers based on various sample types relevant to pan-creatic cancer.
基金项目
国家自然科学基金(81972324)
中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-002)
中国医学科学院医学与健康科技创新工程项目(2022-I2M-C&T-B-030)
中央高校基本科研业务费专项(3332022004)
NETL
NSTL
万方数据