Post-translational modification in pancreatic cancer:current status and prospects
Pancreatic cancer has an extremely high malignancy degree.Due to the significant ad-vances in the diagnosis and treatment of pancreatic cancer in recent years,the survival period for late-stage pancreatic cancer patients has notably extended.However,the 5-year survival rate remains low.There is an urgent need for more effective treatment methods,particularly in the regulation of key molecules in the signaling pathways of pancreatic cancer,which may hold the hope for curing this disease.Post-translational modification of proteins is one of the important ways to regulate protein structure and function.It involves processing different functional groups,transportation,and binding to substrate proteins,affecting the physi-cochemical properties,spatial conformation,and binding capacity of the substrate proteins.This,in turn,regulates substrate proteins in various aspects,such as localization,stability,and activity.Research has shown that post-translational modifications play a significant role in regulating pancreatic cancer in terms of proliferation,invasion,apoptosis,the cell cycle,and resistance to radiotherapy and chemotherapy.Further research into their role in the development of pancreatic cancer and targeted interventions may provide ef-fective treatment methods for this disease.This article primarily focuses on the current research status of post-translational modifications in pancreatic cancer and looks ahead to their potential clinical applications.
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