颅内未破裂动脉瘤支架术后沉默性脑梗死患者1年内发生健康生存质量下降的临床危险因素分析
Analysis of clinical risk factors for health-related quality of life decline within 1 year in patients with silent cerebral infarction following intracranial unruptured aneurysm after stent placement
陈若琨 1李文强 1孙剑瑞 1卢玉昭2
作者信息
- 1. 郑州大学第一附属医院神经外科,郑州 450052
- 2. 南昌大学第一附属医院神经外科,南昌 330006
- 折叠
摘要
目的 探索颅内未破裂动脉瘤支架术后无症状性脑梗死患者中在术后1年内出现健康生存质量(HRQOL)下降的危险因素并进行分析.方法 收集2016年1月至2021年12月期间郑州大学第一附属医院和南昌大学第一附属医院的颅内未破裂动脉瘤支架介入治疗术后沉默性脑梗死患者220例.根据患者是否发生HRQOL下降分为HRQOL下降组及HRQOL无下降组.比较两组患者的一般情况,既往病史,动脉瘤相关信息,实验室检查及梗死灶数量及体积,并进行了单因素及多因素逻辑回归分析.结果 51例(23.18％)患者在术后1年出现HRQOL评分下降.比较两组相关特征参数,HRQOL下降组梗塞灶数量高于未下降组(6.08±4.73比11.27±6.22,Z=-5.355,P＜0.05),梗塞灶总体积也高于未下降组(62.74±64.44 比 119.84±79.89,Z=-5.194,P＜0.05),而女性所占比例低于未下降组(75.7％比60.8％,x2=4.373,P＜0.05),多因素回归分析发现梗塞灶数量[比值比(OR)=1.169,P＜0.01]及女性(OR=2.488,P＜0.05)是颅内未破裂动脉瘤支架术后无症状性脑梗塞患者出现1年内HRQOL下降的独立危险因素.结论 颅内未破裂动脉瘤支架术后沉默性脑梗塞患者,如果存在多个梗塞灶数量且为女性,应更加关注1年内的HRQOL结果并提前干预.
Abstract
Objective To investigate the risk factors associated with health-related quality of life(HRQOL)decline occurring within one year following endovascular stenting treatment of unruptured in-tracranial aneurysms in patients with silent cerebral infarctions.Methods The clinical data of 220 pa-tients who underwent endovascular stenting treatment for unruptured intracranial aneurysms between January 2016 and December 2021 at the First Affiliated Hospital of Zhengzhou University and the First Affiliated Hospital of Nanchang University were collected.Patients were categorized into two groups based on the presence of HRQOL decline:HRQOL decline group and group without HRQOL decline.General informa-tion,medical history,aneurysm-related data,laboratory test results and the number and volume of infarcts were compared between the two groups.Both univariate and multivariate logistic regression analyses were performed.Results Among the 220 patients,51(23.18％)experienced HRQOL decline after the treat-ment at 1 year follow-up.The patients with HRQOL decline had more number of infarcts(6.08±4.73 vs.11.27±6.22,Z=-5.355,P＜0.05)and larger volume of infarcts(62.74±64.44 vs.119.84± 79.89,Z=-5.194,P＜0.05)than those without HRQOL decline.However,the proportion of female was lower in patients with HRQOL decline than in those without HRQOL decline(75.7％vs.60.8％,x2=4.373,P＜0.05).Multivariate regression analysis identified number of infarcts[odds ratio(OR)=1.169,P＜0.01)and female(OR=2.488,P＜0.05)as independent risk factors for HRQOL decline in patients with unruptured intracranial aneurysms treated with endovascular stenting treatment.Conclusion For patients with unruptured intracranial aneurysm undergoing silent cerebral infarction after stent place-ment,women with multiple infarcts should pay more attention to the HRQOL results within 1 year and ad-vanced intervention treatment.
关键词
颅内未破裂动脉瘤/介入支架治疗/沉默性脑梗死/健康生存质量下降/危险因素Key words
Intracranial unruptured aneurysm/Stent placement/Silent cerebral infarction/Health-related quality of life decline/Risk factors引用本文复制引用
出版年
2024
NETL
NSTL
万方数据