Progress and prospects of neoadjuvant therapy in gastric surgery
Gastric cancer is the fifth most common malignant tumor and the fourth leading cause of cancer-related deaths worldwide.Due to the insufficient implementation of early screening and the insidious and rapid progression of gastric cancer,most gastric cancer patients in China have entered the stage of pro-gression at the initial diagnosis.At present,neoadjuvant therapy is increasingly valued in the clinical diag-nosis and treatment of advanced gastric cancer.It can reduce tumor clinical staging,improve surgical R0 resection rate,and reduce the risk of postoperative recurrence and metastasis,thereby prolonging patient survival.In recent years,multiple clinical studies including our center have shown that neoadjuvant chemo-therapy combined with immunotherapy significantly improves the pathological response rate of advanced gas-tric cancer patients compared to chemotherapy alone.However,there are still a series of issues worth ex-ploring.The author elaborates on the development process and current hot topics of neoadjuvant therapy for advanced gastric cancer from two perspectives:clinical and basic transformation,by reviewing relevant re-search both domestically and internationally.
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